Interaction kinetics reveal distinct properties of conformational ensembles of three‐repeat and four‐repeat tau proteins
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14339
Abstract: Tau protein is an intrinsically disordered protein. Its physiological state is best described as a conformational ensemble (CE) of metastable structures interconverting on the local and molecular scale. The monoclonal antibody DC39C recognizes a linear… read more here.
Keywords: tau proteins; tau; three repeat; interaction kinetics ... See more keywords
Resveratrol targeting tau proteins, amyloid‐beta aggregations, and their adverse effects: An updated review
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6732
Abstract: Resveratrol (Res) is a non‐flavonoid compound with pharmacological actions such as antioxidant, antiinflammatory, hepatoprotective, antidiabetes, and antitumor. This plant‐derived chemical has a long history usage in treatment of diseases. The excellent therapeutic impacts of Res… read more here.
Keywords: tau proteins; amyloid beta; resveratrol targeting; review ... See more keywords
Tau Proteins and Tauopathies in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0574-1
Abstract: Alzheimer’s disease (AD) is characterized by progressive memory loss and cognitive function deficits. There are two major pathological hallmarks that contribute to the pathogenesis of AD which are the presence of extracellular amyloid plaques composed… read more here.
Keywords: proteins tauopathies; tau; tauopathies alzheimer; alzheimer disease ... See more keywords
Investigation of the Structure of Full-Length Tau Proteins with Coarse-Grained and All-Atom Molecular Dynamics Simulations.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00381
Abstract: Tau proteins not only have many important biological functions but also are associated with several neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease (AD). However, it is still a challenge to identify the atomic… read more here.
Keywords: full length; tau proteins; length tau; structure ... See more keywords
A receptor that lets dementia-associated tau proteins into neurons
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/d41586-020-00874-z
Abstract: In many neurodegenerative disorders, the spread of protein aggregates underlies disease progression in the brain. A receptor molecule has now been found that mediates the neuronal uptake of one such harmful protein. LRP1 protein mediates… read more here.
Keywords: tau proteins; associated tau; dementia associated; receptor lets ... See more keywords
Blood-based immunoassay of tau proteins for early diagnosis of Alzheimer's disease using surface plasmon resonance fiber sensors
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c7ra11637c
Abstract: We present the immunoassay of tau proteins (total tau and phosphorylated tau) in human sera using surface plasmon resonance (SPR) fiber sensors. This assay aimed at harvesting the advantages of using both SPR fiber sensors… read more here.
Keywords: immunoassay tau; fiber sensors; tau proteins; phosphorylated tau ... See more keywords
Possible concurrence of TDP‐43, tau and other proteins in amyotrophic lateral sclerosis/frontotemporal lobar degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Neuropathology"
DOI: 10.1111/neup.12428
Abstract: Transactivation response DNA‐binding protein 43 kDa (TDP‐43) has been regarded as a major component of ubiquitin‐positive/tau‐negative inclusions of motor neurons and the frontotemporal cortices in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Neurofibrillary tangles… read more here.
Keywords: tdp tau; tau; tdp; tau proteins ... See more keywords
Assessment of Amyloid Forming Tendency of Peptide Sequences from Amyloid Beta and Tau Proteins Using Force-Field, Semi-Empirical, and Density Functional Theory Calculations
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063244
Abstract: A wide variety of neurodegenerative diseases are characterized by the accumulation of protein aggregates in intraneuronal or extraneuronal brain regions. In Alzheimer’s disease (AD), the extracellular aggregates originate from amyloid-β proteins, while the intracellular aggregates… read more here.
Keywords: force field; peptide sequences; sequences amyloid; theory calculations ... See more keywords