APOE Antibody Inhibits Aβ‐Associated Tau Seeding and Spreading in a Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26351
Abstract: APOE is the strongest genetic factor for late‐onset Alzheimer's disease (AD). A specific conformation of the ApoE protein is present in amyloid‐β (Aβ) containing plaques. Immunotherapy targeting ApoE in plaques reduces brain Aβ deposits in… read more here.
Keywords: inhibits associated; antibody inhibits; apoe antibody; tau seeding ... See more keywords
Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures
Sign Up to like & getrecommendations! Published in 2021 at "Biological psychiatry"
DOI: 10.1016/j.biopsych.2021.02.973
Abstract: BACKGROUND Obstructive sleep apnea, characterized by sleep fragmentation and chronic intermittent hypoxia (CIH), is a risk factor for Alzheimer's disease (AD) progression. Recent epidemiological studies point to CIH as the best predictor of developing cognitive… read more here.
Keywords: tau; tau seeding; mice; synaptic plasticity ... See more keywords
Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020718
Abstract: Several studies have demonstrated the different characteristics of tau seeding and spreading following intracerebral inoculation in murine models of tau-enriched fractions of brain homogenates from AD and other tauopathies. The present study is centered on… read more here.
Keywords: tau; host tau; seeding spreading; tau seeding ... See more keywords