Tau immunoreactivity in peripheral tissues of human aging and select tauopathies
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.12.031
Abstract: Many studies have been directed at understanding mechanisms of tau aggregation and therapeutics, nearly all focusing on the brain. It is critical to understand the presence of tau in peripheral tissues since this may provide… read more here.
Keywords: tau immunoreactivity; immunoreactivity peripheral; peripheral tissues; nerve elements ... See more keywords
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.12.001
Abstract: During aging, decreased efficiency of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation and autophagic processes in the brain may be a contributing factor in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. Therefore, we… read more here.
Keywords: month old; expression bag3; nrf2 mediates; mediates expression ... See more keywords
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13615
Abstract: Intracellular accumulation of filamentous tau aggregates with progressive neuronal loss is a common characteristic of tauopathies. Although the neurodegenerative mechanism of tau‐associated pathology remains unclear, molecular elements capable of degrading and/or sequestering neurotoxic tau species… read more here.
Keywords: p62 sqstm1; tau; accumulation; mice ... See more keywords