Tau tubulin kinase is required for spermatogenesis and development of motile cilia in planarian flatworms
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-10-0663
Abstract: Cilia are microtubule-based structures that protrude from the apical surface of cells to mediate motility, transport, intracellular signaling, and environmental sensing. Tau tubulin kinases (TTBKs) destabilize microtubules by phosphorylating microtubule-associated proteins (MAPs) of the MAP2/Tau… read more here.
Keywords: smed ttbk; tau tubulin; development; motile cilia ... See more keywords
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1101/2022.05.06.490937
Abstract: Tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) are highly homologous kinases that are expressed and mediate disease-relevant pathways predominantly in the brain. Distinct roles for TTBK1 and TTBK2 have been delineated. While efforts… read more here.
Keywords: ciliogenesis; modulation tau; ttbk2; ttbk1 ttbk2 ... See more keywords
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.00415
Abstract: Tauopathy is a type of dementia defined by the accumulation of filamentous tau inclusions in neural cells. Most types of dementia in the elderly, including Alzheimer’s disease, are tauopathies. Although it is believed that tau… read more here.
Keywords: tau; expression; tau tubulin; neuronal dysfunction ... See more keywords
Visualization of Tau–Tubulin Interaction in a Living Cell Using Bifluorescence Complementation Technique
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19102978
Abstract: Tau is a neuron-specific microtubule-binding protein that stabilizes microtubules. It is generally thought that highly phosphorylated tau dissociates from microtubules and becomes insoluble aggregates, leading to neuronal degeneration. Due to the implication of tau aggregation… read more here.
Keywords: tau; tubulin interaction; tau tubulin; tubulin ... See more keywords