Tauroursodeoxycholic Acid Improves Nonalcoholic Fatty Liver Disease by Regulating Gut Microbiota and Bile Acid Metabolism.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c04630
Abstract: Tauroursodeoxycholic acid (TUDCA) is a synthetic bile salt that has demonstrated efficacy in the management of hepatobiliary disorders. However, its specific mechanism of action in preventing and treating nonalcoholic fatty liver disease (NAFLD) remains incompletely… read more here.
Keywords: tauroursodeoxycholic acid; nonalcoholic fatty; bile; acid ... See more keywords
Tauroursodeoxycholic acid (TUDCA) counters osteoarthritis by regulating intracellular cholesterol levels and membrane fluidity of degenerated chondrocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm00426b
Abstract: Cholesterol and lipid metabolism are associated with osteoarthritis (OA) in human cartilage. High cholesterol levels in OA chondrocytes leads to decreased membrane fluidity and blocks the signaling cascade associated with the expression of chondrogenic genes.… read more here.
Keywords: cholesterol levels; tudca; membrane fluidity; cholesterol ... See more keywords
Corticosterone‐Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.70027
Abstract: Major depressive disorder increases cardiovascular risk through stress‐induced elevated cortisol levels. Tauroursodeoxycholic acid (TUDCA), a bile acid, has been reported to have anti‐inflammatory, anti‐depressive and cardioprotective effects. However, the effects of stress‐induced myocardial dysfunctions remain… read more here.
Keywords: corticosterone induced; myocardial dysfunctions; tauroursodeoxycholic acid; induced myocardial ... See more keywords
Investigating the effects of tauroursodeoxycholic acid (TUDCA) in mitigating endoplasmic reticulum stress and cellular responses in Pak choi.
Sign Up to like & getrecommendations! Published in 2024 at "Physiologia plantarum"
DOI: 10.1111/ppl.14246
Abstract: The accumulation of misfolded proteins in the endoplasmic reticulum (ER) within plant cells due to unfavourable conditions leads to ER stress. This activates interconnected pathways involving reactive oxygen species (ROS) and unfolded protein response (UPR),… read more here.
Keywords: tauroursodeoxycholic acid; pak choi; stress; endoplasmic reticulum ... See more keywords
Tauroursodeoxycholic Acid Ameliorates Lipopolysaccharide-Induced Depression Like Behavior in Mice via the Inhibition of Neuroinflammation and Oxido-Nitrosative Stress
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DOI: 10.1159/000494139
Abstract: Depression is a mental disease that causes severe economic and social burdens. The mechanism for the onset of depression remains largely unknown. Recently, more and more attention is being given to the role of neuroinflammation… read more here.
Keywords: depression; oxido nitrosative; neuroinflammation; tauroursodeoxycholic acid ... See more keywords
Large-scale production of tauroursodeoxycholic acid products through fermentation optimization of engineered Escherichia coli cell factory
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Cell Factories"
DOI: 10.1186/s12934-019-1076-2
Abstract: BackgroundBear bile powder is a valuable medicinal material characterized by high content of tauroursodeoxycholic acid (TUDCA) at a certain ratio to taurochenodeoxycholic acid (TCDCA). We had created an engineered E. coli harboring two-step bidirectional oxidative… read more here.
Keywords: bile powder; fermentation; tauroursodeoxycholic acid; powder ... See more keywords
Tauroursodeoxycholic Acid Reduces Neuroinflammation but Does Not Support Long Term Functional Recovery of Rats with Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071501
Abstract: The bile acid tauroursodeoxycholic acid (TUDCA) reduces cell death under oxidative stress and inflammation. Implants of bone marrow-derived stromal cells (bmSC) are currently under investigation in clinical trials of spinal cord injury (SCI). Since cell… read more here.
Keywords: tudca; tauroursodeoxycholic acid; injury; spinal cord ... See more keywords
Effect of Tauroursodeoxycholic Acid on Inflammation after Ocular Alkali Burn
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911717
Abstract: Inflammation is the main cause of corneal and retinal damage in an ocular alkali burn (OAB). The aim of this study was to investigate the effect of tauroursodeoxycholic acid (TUDCA) on ocular inflammation in a… read more here.
Keywords: inflammation; tauroursodeoxycholic acid; effect tauroursodeoxycholic; ocular alkali ... See more keywords
Possible Role of Tauroursodeoxycholic Acid (TUDCA) and Antibiotic Administration in Modulating Human Gut Microbiota in Home Enteral Nutrition Therapy for the Elderly: A Case Report
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25137115
Abstract: Tauroursodeoxycholic acid (TUDCA) increases the influx of primary bile acids into the gut. Results obtained on animal models suggested that Firmicutes and Proteobacteria phyla are more resistant to bile acids in rats. As part of… read more here.
Keywords: tauroursodeoxycholic acid; role; gut microbiota; acid tudca ... See more keywords