Tauroursodeoxycholic acid (TUDCA) counters osteoarthritis by regulating intracellular cholesterol levels and membrane fluidity of degenerated chondrocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm00426b
Abstract: Cholesterol and lipid metabolism are associated with osteoarthritis (OA) in human cartilage. High cholesterol levels in OA chondrocytes leads to decreased membrane fluidity and blocks the signaling cascade associated with the expression of chondrogenic genes.… read more here.
Keywords: cholesterol levels; tudca; membrane fluidity; cholesterol ... See more keywords
Tauroursodeoxycholic Acid Ameliorates Lipopolysaccharide-Induced Depression Like Behavior in Mice via the Inhibition of Neuroinflammation and Oxido-Nitrosative Stress
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DOI: 10.1159/000494139
Abstract: Depression is a mental disease that causes severe economic and social burdens. The mechanism for the onset of depression remains largely unknown. Recently, more and more attention is being given to the role of neuroinflammation… read more here.
Keywords: depression; oxido nitrosative; neuroinflammation; tauroursodeoxycholic acid ... See more keywords
Large-scale production of tauroursodeoxycholic acid products through fermentation optimization of engineered Escherichia coli cell factory
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DOI: 10.1186/s12934-019-1076-2
Abstract: BackgroundBear bile powder is a valuable medicinal material characterized by high content of tauroursodeoxycholic acid (TUDCA) at a certain ratio to taurochenodeoxycholic acid (TCDCA). We had created an engineered E. coli harboring two-step bidirectional oxidative… read more here.
Keywords: bile powder; fermentation; tauroursodeoxycholic acid; powder ... See more keywords
Tauroursodeoxycholic Acid Reduces Neuroinflammation but Does Not Support Long Term Functional Recovery of Rats with Spinal Cord Injury
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DOI: 10.3390/biomedicines10071501
Abstract: The bile acid tauroursodeoxycholic acid (TUDCA) reduces cell death under oxidative stress and inflammation. Implants of bone marrow-derived stromal cells (bmSC) are currently under investigation in clinical trials of spinal cord injury (SCI). Since cell… read more here.
Keywords: tudca; tauroursodeoxycholic acid; injury; spinal cord ... See more keywords
Effect of Tauroursodeoxycholic Acid on Inflammation after Ocular Alkali Burn
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DOI: 10.3390/ijms231911717
Abstract: Inflammation is the main cause of corneal and retinal damage in an ocular alkali burn (OAB). The aim of this study was to investigate the effect of tauroursodeoxycholic acid (TUDCA) on ocular inflammation in a… read more here.
Keywords: inflammation; tauroursodeoxycholic acid; effect tauroursodeoxycholic; ocular alkali ... See more keywords