The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30II and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.05.007
Abstract: The human T-cell leukemia virus type-1 (HTLV-1) is an oncoretrovirus that infects and transforms CD4+ T-cells and causes adult T-cell leukemia/lymphoma (ATLL) -an aggressive lymphoproliferative disease that is highly refractive to most anticancer therapies. The… read more here.
Keywords: htlv; htlv induced; oncoproteins tax; tax hbz ... See more keywords
The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
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DOI: 10.1371/journal.ppat.1009919
Abstract: Viral infections are known to hijack the transcription and translation of the host cell. However, the extent to which viral proteins coordinate these perturbations remains unclear. Here we used a model system, the human T-cell… read more here.
Keywords: tax; tax hbz; mrna splicing; splicing landscape ... See more keywords