Treatment outcomes of advanced/metastatic extramammary Paget's disease in Korean patients: KCSG-RC20-06.
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DOI: 10.1002/cam4.6190
Abstract: BACKGROUND Extramammary Paget's disease (EMPD) is rare. There are no standard treatments due to its rarity and few clinical trials. METHODS The objective of this multicenter study was to investigate treatment outcomes of Korean patients… read more here.
Keywords: taxane; treatment; advanced metastatic; chemotherapy ... See more keywords
Pertuzumab, trastuzumab and taxane-based treatment for visceral organ metastatic, trastuzumab-naïve breast cancer: real-life practice outcomes
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DOI: 10.1007/s00280-018-3712-7
Abstract: PurposeIn this study, we aimed to describe the real-life practice outcomes of pertuzumab–trastuzumab–taxane (PTT) combination in visceral organ metastatic, trastuzumab-naive breast cancer (BC) patients.MethodsThis study was conducted by Turkish Oncology Group and included 317 patients’… read more here.
Keywords: pertuzumab trastuzumab; trastuzumab taxane; metastatic trastuzumab; taxane ... See more keywords
Incidence of taxane-induced peripheral neuropathy receiving treatment and prescription patterns in patients with breast cancer
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DOI: 10.1007/s00520-017-3631-x
Abstract: PurposeTaxane-induced peripheral neuropathy (TIPN) can affect quality of life and treatment outcomes in breast cancer patients. Despite the high incidence, treatment of PN has not been established. This study aimed to evaluate the incidence, risk… read more here.
Keywords: incidence; treatment; taxane; receiving treatment ... See more keywords
Biomarker analysis of the GATSBY study of trastuzumab emtansine versus a taxane in previously treated HER2-positive advanced gastric/gastroesophageal junction cancer
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DOI: 10.1007/s10120-018-00923-7
Abstract: BackgroundPrespecified exploratory biomarker analyses of the phase II/III GATSBY study (NCT01641939) assessed whether patient subgroups experienced a survival benefit from trastuzumab emtansine (T-DM1) versus taxane therapy, and to advance understanding of HER2-positive advanced gastric/gastroesophageal junction… read more here.
Keywords: her2 positive; versus taxane; taxane; versus ... See more keywords
Second-line chemotherapy using taxane in patients with advanced gastric cancer who presented with severe peritoneal metastasis: a multicenter retrospective study
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DOI: 10.1007/s10147-020-01802-x
Abstract: Individuals with advanced gastric cancer (AGC) who present with severe peritoneal metastasis (SPM) have poor prognosis. This study aimed to evaluate efficacy and safety of second-line treatment for patients with such condition. This retrospective study… read more here.
Keywords: line; taxane; study; line chemotherapy ... See more keywords
General Synthetic Approach to Diverse Taxane Cores.
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DOI: 10.1021/jacs.2c10272
Abstract: Chemical synthesis of natural products is typically inspired by the structure and function of a target molecule. When both factors are of interest, such as in the case of taxane diterpenoids, a synthesis can both… read more here.
Keywords: approach diverse; diverse taxane; taxane cores; taxane ... See more keywords
Neurotoxicity induced by taxane-derived drugs: Analysis of the FAERS Database 2017-2021.
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DOI: 10.1080/14740338.2023.2193391
Abstract: OBJECTIVES Taxane-related neurotoxicity is a frequent clinical problem but lacks postmarketing data regarding neurological disorders. This study aimed to evaluate the potential association between neurological adverse events and several taxane-derived drugs via the Food and… read more here.
Keywords: taxane; neurological adverse; analysis; derived drugs ... See more keywords
Strategies for the drug discovery and development of taxane anticancer therapeutics
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DOI: 10.1080/17460441.2022.2131766
Abstract: ABSTRACT Introduction Paclitaxel and docetaxel have been extensively used in the clinic over the past three decades. Although the patents of these first-generation taxanes have expired, their clinical applications, particularly new formulations and combination therapies,… read more here.
Keywords: discovery development; taxane; generation taxanes; drug ... See more keywords
Acupuncture and integrative oncology for taxane-induced peripheral neuropathy: a randomized multicentered study
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DOI: 10.1136/ijgc-2022-004004
Abstract: Objective To compare the effectiveness of acupuncture alone or with additional integrative oncology modalities for taxane-induced peripheral neuropathy-related symptoms in patients with gynecological and breast cancer. Methods The study was a prospective evaluation of patients… read more here.
Keywords: oncology; integrative oncology; acupuncture; taxane ... See more keywords
SK3 Gene Polymorphism Is Associated with Taxane Neurotoxicity and Cell Calcium Homeostasis
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DOI: 10.1158/1078-0432.ccr-18-0870
Abstract: Purpose: Taxane-induced peripheral neuropathy is a common side effect induced by anticancer agents, and no drug capable of preventing its occurrence or ameliorating its long-term course has been identified. The physiology of taxane neuropathy is… read more here.
Keywords: homeostasis; sk3; taxane; taxane neurotoxicity ... See more keywords
Microtubule Engagement with Taxane Is Altered in Taxane-Resistant Gastric Cancer
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DOI: 10.1158/1078-0432.ccr-19-3018
Abstract: Purpose: Although taxane-based therapy is standard treatment for advanced gastric cancer, a majority of patients exhibit intrinsic resistance to taxanes. Here, we aim to identify the molecular basis of taxane resistance in gastric cancer. Experimental… read more here.
Keywords: taxane resistance; drug; taxane; cancer ... See more keywords