Characterization and expression analysis of genes encoding Taxol biosynthetic enzymes in Taxus spp.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Forestry Research"
DOI: 10.1007/s11676-021-01290-3
Abstract: Taxol (Paclitaxel), an important anticancer drug, is derived at very low yields from Taxus (yew) species that grow very slowly. In the present study, thirteen genes that encode enzymes involved in Taxol biosynthesis in Taxus… read more here.
Keywords: expression analysis; taxus spp; taxol; characterization expression ... See more keywords
miR‐29c regulates resistance to paclitaxel in nasopharyngeal cancer by targeting ITGB1
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2019.02.012
Abstract: &NA; Paclitaxel (Taxol) is an anticancer taxane drug commonly used in the treatment of nasopharyngeal carcinoma (NPC). However, resistance to paclitaxel is a major difficulty in developing an effective therapy against NPC. MicroRNAs (miRNAs) are… read more here.
Keywords: npc; taxol; resistance; resistance paclitaxel ... See more keywords
Strategies and Lessons Learned from Total Synthesis of Taxol.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.2c00763
Abstract: Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source anticancer drug ever produced and one of the most common prescriptions in the treatment of breast, lung, and ovarian cancers, saving countless lives around… read more here.
Keywords: taxol; learned total; lessons learned; strategies lessons ... See more keywords
Comparative transcriptome analysis of a taxol-producing endophytic fungus, Aspergillus aculeatinus Tax-6, and its mutant strain
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67614-1
Abstract: Taxol is a rare but extremely effective antitumor agent extracted from Taxus yew barks. Taxus plants are valuable and rare species, and the production of taxol from them is a complex process. Therefore, taxol-producing endophytic… read more here.
Keywords: taxol producing; tax; taxol; aculeatinus tax ... See more keywords
LncRNA DLEU2 contributes to Taxol resistance of gastric cancer cells through regulating the miR-30c-5p-LDHA axis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemotherapy"
DOI: 10.1080/1120009x.2023.2203606
Abstract: Gastric cancer (GC) is a human malignancy which is associated with high mortality rate and poor prognosis. In addition to surgery, chemo- and radio-therapies are effective strategies against GC at advanced or metastatic stage. Taxol… read more here.
Keywords: dleu2; taxol; mir 30c; resistance ... See more keywords
Role of female-predominant MYB39-bHLH13 complex in sexually dimorphic accumulation of taxol in Taxus media
Sign Up to like & getrecommendations! Published in 2022 at "Horticulture Research"
DOI: 10.1093/hr/uhac062
Abstract: Abstract Taxus trees are major natural sources for the extraction of taxol, an anti-cancer agent used worldwide. Taxus media is a dioecious woody tree with high taxol yield. However, the sexually dimorphic accumulation of taxoids… read more here.
Keywords: taxus media; taxol; tmmyb39; sexually dimorphic ... See more keywords
Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2023 at "Mediators of Inflammation"
DOI: 10.1155/2023/5604103
Abstract: Axonal regeneration has been the research focus in the field of clinical treatment for spinal cord injury (SCI). The growth and extension of neuronal axons is a dynamic biological process mediated by the cytoskeleton, and… read more here.
Keywords: dose taxol; taxol; axonal regeneration; low dose ... See more keywords
LC-MS based sphingolipidomic study on A549 human lung adenocarcinoma cell line and its taxol-resistant strain
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4714-x
Abstract: BackgroundResistance to chemotherapy drugs (e.g. taxol) has been a major obstacle in successful cancer treatment. In A549 human lung adenocarcinoma, acquired resistance to the first-line chemotherapy taxol has been a critical problem in clinics. Sphingolipid… read more here.
Keywords: lung adenocarcinoma; taxol; human lung; taxol resistant ... See more keywords
Transcriptome analysis of a taxol-producing endophytic fungus Cladosporium cladosporioides MD2
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DOI: 10.1186/s13568-018-0567-6
Abstract: The shortage of molecular information for taxol-producing fungi has greatly impeded the understanding of fungal taxol biosynthesis mechanism. In this study, the transcriptome of one taxol-producing endophytic fungus Cladosporium cladosporioides MD2 was sequenced for the… read more here.
Keywords: endophytic fungus; taxol producing; taxol; producing endophytic ... See more keywords
Pembrolizumab (pembro) with paclitaxel (taxol) or capecitabine (cape) as early treatment of metastatic triple-negative breast cancer (mTNBC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.1015
Abstract: 1015 Background: Atezolizumab (anti-PD-L1) plus nab-paclitaxel was shown to improve outcomes in mTBNC in a phase III clinical trial. Subjects were required to be > 12 months from curative-intent therapy in this trial. It remains… read more here.
Keywords: trial; chemo; taxol; paclitaxel ... See more keywords
Transcriptome-based signature predicts the effect of taxol in serous ovarian cancer
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DOI: 10.1371/journal.pone.0192812
Abstract: Taxol is a widely used chemotherapy drug used clinically for ovarian cancer, although the response to Taxol among individuals varies due to the heterogeneity among ovarian cancer patients. In this work, we analyzed differences in… read more here.
Keywords: serous ovarian; taxol score; taxol; effect ... See more keywords