Paraspeckle Protein NONO Promotes TAZ Phase Separation in the Nucleus to Drive the Oncogenic Transcriptional Program.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202102653
Abstract: The Hippo pathway effector TAZ promotes cellular growth, survival, and stemness through regulating gene transcription. Recent studies suggest that TAZ liquid-liquid phase separation (LLPS) compartmentalizes key cofactors to activate transcription. However, how TAZ LLPS is… read more here.
Keywords: protein nono; paraspeckle protein; phase separation; taz ... See more keywords
SDHA/B reduction promotes hepatocellular carcinoma by facilitating the deNEDDylation of cullin1 and stabilizing YAP/TAZ.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32621
Abstract: BACKGROUND & AIMS Succinate dehydrogenase enzyme (SDH) is frequently diminished in Hepatocellular carcinoma (HCC) patient samples, and SDH reduction is associated with elevated succinate level and poor prognosis in HCC patients. But the underlying mechanisms… read more here.
Keywords: hcc; sdha reduction; taz; yap taz ... See more keywords
TAZ/WWTR1 mediates liver mesothelial–mesenchymal transition induced by stiff extracellular environment, TGF‐β1, and lysophosphatidic acid
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30750
Abstract: Mesothelial cells cover the surface of the internal organs and the walls of body cavities, facilitating the movement between organs by secretion of a lubricating fluid. Upon injury, mesothelial cells undergo a mesothelial–mesenchymal transition (MMT)… read more here.
Keywords: taz; mesenchymal transition; mesothelial mesenchymal; mesothelial cells ... See more keywords
Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8910-2_9
Abstract: The transcriptional coactivator with PDZ-binding motif (TAZ), which is encoded by the WWTR1 gene, is a key transcriptional effector of the Hippo signaling pathway. TAZ function has been implicated in a variety of developmental processes and… read more here.
Keywords: microscopy; taz; study; immunofluorescence microscopy ... See more keywords
(-)-Epigallocatechin-3-gallate stimulates myogenic differentiation through TAZ activation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.049
Abstract: Muscle loss is a typical process of aging. Green tea consumption is known to slow down the progress of aging. Their underlying mechanisms, however, remain largely unknown. In this study, we investigated the effect of… read more here.
Keywords: epigallocatechin gallate; differentiation taz; taz; myogenic differentiation ... See more keywords
Three acceptors based bipolar materials with tunable excited state natures and applications as non-doped blue emitters and hosts in OLEDs
Sign Up to like & getrecommendations! Published in 2018 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2018.03.030
Abstract: Abstract Four bipolar materials including of CN-TAZ-1Cz, CN-TAZ-2Cz, CN-TAZ-3Cz and CN-TAZ-4Cz were successfully designed and synthesized by incorporating electron-accepting cyano, 1, 2, 4-triazole and pyridine and electron-donating carbazole. The synthesized materials displayed deep-blue and blue… read more here.
Keywords: excited state; taz; bipolar materials; non doped ... See more keywords
Dasatinib sensitises KRAS-mutant cancer cells to mitogen-activated protein kinase kinase inhibitor via inhibition of TAZ activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2018.05.013
Abstract: PURPOSE Oncogenic KRAS mutations occur frequently in solid tumours, but no clinically applicable targeted strategy is yet available for treating human cancers with mutant KRAS. Here we aimed to identify a strategy for the treatment… read more here.
Keywords: inhibitor; kinase; taz; dasatinib ... See more keywords
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.10.030
Abstract: The transcriptional regulators YAP and TAZ play important roles in development, physiology, and tumorigenesis and are negatively controlled by the Hippo pathway. It is yet unknown why the YAP/ TAZ proteins are frequently activated in… read more here.
Keywords: yap taz; cancer metastasis; taz;
Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101425
Abstract: Transcription factor NRF2 orchestrates a cellular defense against oxidative stress and, so far, has been involved in tumor progression by providing a metabolic adaptation to tumorigenic demands and resistance to chemotherapeutics. In this study, we… read more here.
Keywords: factor nrf2; transcription factor; taz; tumorigenesis ... See more keywords
High expression of TAZ serves as a novel prognostic biomarker and drives cancer progression in renal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2019.02.001
Abstract: &NA; Renal cell carcinomas are a group of most common renal malignancies whose clinical intervention is complicated by the lack of early diagnosis and reliable prognosis biomarkers, insensitive radiotherapy and chemotherapy and expensive molecular‐targeted drugs.… read more here.
Keywords: taz; taz expression; cancer; cell ... See more keywords
Interaction of LEF1 with TAZ is necessary for the osteoblastogenic activity of Wnt3a
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28711-4
Abstract: Canonical Wnt signalling plays an important role in osteoblast differentiation and bone formation. However, the molecular mechanisms by which canonical Wnt signalling exerts its osteoblastogenic effect remain elusive. Here, we investigated the relationship between lymphoid… read more here.
Keywords: lef1 taz; interaction lef1; taz; osteoblast differentiation ... See more keywords