Abstract 5229: Discovery of novel potent allosteric inhibitors of YAP/TAZ-TEAD transcription for the treatment of multiple solid tumor types addicted to Hippo signaling
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DOI: 10.1158/1538-7445.am2020-5229
Abstract: The Hippo pathway is a highly conserved signaling pathway across higher-order vertebrates and a key modulator of developmental biology. Both genetic aberrations as well as non-genetic dysregulation of the pathway lead to constitutive nuclear localization… read more here.
Keywords: taz tead; inhibitors yap; allosteric inhibitors; solid tumor ... See more keywords
Abstract 1646: IK-930, a paralog-selective TEAD inhibitor for treating YAP/TAZ-TEAD dependent cancers
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DOI: 10.1158/1538-7445.am2023-1646
Abstract: The Hippo signaling cascade regulates cell proliferation and survival, as well as overall tissue homeostasis. These functions are mediated by the TEAD family of transcription factors which, when bound to the co-activators YAP or TAZ,… read more here.
Keywords: tead inhibitor; taz tead; yap taz; inhibitor ... See more keywords
Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex
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DOI: 10.1371/journal.pone.0266143
Abstract: Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically… read more here.
Keywords: taz; aurintricarboxylic acid; taz tead; transcriptional complex ... See more keywords