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   Articles with "taz tead" as a keyword



CNSC-44. TARGETING OF THE YAP/TAZ-TEAD AXIS DIMINISHES VIABILITY AND DIFFERENTIATION POTENTIAL IN PEDIATRIC HIGH-GRADE GLIOMA

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae165.0200

Abstract: Pediatric high-grade gliomas (pHGGs) are invasive and fast-growing brain malignancies. They account for up to 40% of all brain tumor-related deaths in childhood. Genetic alterations that characterize these gliomas include H3 onco-histone mutations and genetic… read more here.

Keywords: high grade; taz tead; yap taz; tumor cells ... See more keywords

Abstract 5229: Discovery of novel potent allosteric inhibitors of YAP/TAZ-TEAD transcription for the treatment of multiple solid tumor types addicted to Hippo signaling

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recommendations! Published in 2020 at "Cancer Research"

DOI: 10.1158/1538-7445.am2020-5229

Abstract: The Hippo pathway is a highly conserved signaling pathway across higher-order vertebrates and a key modulator of developmental biology. Both genetic aberrations as well as non-genetic dysregulation of the pathway lead to constitutive nuclear localization… read more here.

Keywords: taz tead; inhibitors yap; allosteric inhibitors; solid tumor ... See more keywords

Abstract 1646: IK-930, a paralog-selective TEAD inhibitor for treating YAP/TAZ-TEAD dependent cancers

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-1646

Abstract: The Hippo signaling cascade regulates cell proliferation and survival, as well as overall tissue homeostasis. These functions are mediated by the TEAD family of transcription factors which, when bound to the co-activators YAP or TAZ,… read more here.

Keywords: tead inhibitor; taz tead; yap taz; inhibitor ... See more keywords

Abstract 5644: Identification of alexidine as a novel small molecule inhibitor of TAZ-TEAD interaction in breast cancer cell migration

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-5644

Abstract: Breast cancer (BC) is the most commonly diagnosed malignancy in women, with a risk of distant metastases after a primary tumor has developed. Despite concerns about the aggressive pathology of metastatic BC (MBC), current medical… read more here.

Keywords: cancer; tead interaction; taz tead; breast cancer ... See more keywords

Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0266143

Abstract: Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically… read more here.

Keywords: taz; aurintricarboxylic acid; taz tead; transcriptional complex ... See more keywords