Time–Kill Analysis of Ceftolozane/Tazobactam Efficacy Against Mucoid Pseudomonas aeruginosa Strains from Cystic Fibrosis Patients
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DOI: 10.1007/s40121-017-0176-8
Abstract: IntroductionMucoid Pseudomonas aeruginosa (MP) strains in cystic fibrosis (CF) patients are thought to initiate the chronic infection stage of CF and are associated with pulmonary function decline.ObjectivesThe purpose of this study was to assess the… read more here.
Keywords: tazobactam; kill analysis; ceftolozane tazobactam; time kill ... See more keywords
Efficacy of ceftolozane/tazobactam, alone and in combination with colistin, against multidrug-resistant Pseudomonas aeruginosa in an in vitro biofilm pharmacodynamic model.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.01.010
Abstract: OBJECTIVES Ceftolozane/tazobactam is a potential tool for infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa), but its efficacy against some difficult-to-treat infections has not been well defined. METHODS Using an in vitro pharmacodynamic biofilm… read more here.
Keywords: tazobactam; combination; colistin; ceftolozane tazobactam ... See more keywords
The use of ceftolozane-tazobactam in the treatment of complicated intra-abdominal infections and urinary tract infections-A meta-analysis of randomized controlled trials.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.11.015
Abstract: OBJECTS This study aims to assess the clinical efficacy and safety of ceftolozane-tazobactam in the treatment of complicated intra-abdominal infection (cIAI) and complicated urinary tract infection (cUTI) in adult patients through meta-analysis. METHODS PubMed, Embase,… read more here.
Keywords: tazobactam; tazobactam treatment; ceftolozane tazobactam; rate ... See more keywords
Real life experience with ceftolozane/tazobactam therapy for Pseudomonas aeruginosa bacteremia
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DOI: 10.1080/1120009x.2021.1888032
Abstract: Ceftolozane/tazobactam is a b-lactam/b-lactamase inhibitor combination indicated for complicated urinary tract/intra-abdominal infections and pneumonia. Although promising in-vitro activity has been demonstrated against carbapenem resistant Pseudomonas aeruginosa, clinical evidence supporting efficacy of ceftolozane/tazobactam in treating bacteremia… read more here.
Keywords: therapy; bacteremia; aeruginosa; ceftolozane tazobactam ... See more keywords
1319. Pharmacokinetics of Ceftolozane/Tazobactam in Patients with Burns
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DOI: 10.1093/ofid/ofaa439.1501
Abstract: Antimicrobial dosing in moderate/severe burns patients is complicated due to the potential unpredictable hyperdynamic pathophysiologic states including 1) hypoproteinemia, 2) acute kidney injury and 3) onset of septicemia. Therefore, distribution assumptions about the population pharmacokinetic… read more here.
Keywords: tazobactam; thickness burns; 1319 pharmacokinetics; compartment ... See more keywords
Comparative Activity of Newer β-Lactam/β-Lactamase Inhibitor Combinations against Pseudomonas aeruginosa Isolates from United States Medical Centers (2020-2021).
Sign Up to like & getrecommendations! Published in 2022 at "International journal of antimicrobial agents"
DOI: 10.1093/ofid/ofac492.708
Abstract: OBJECTIVES To evaluate the in vitro activity of ceftazidime-avibactam, ceftolozane-tazobactam, meropenem-vaborbactam, imipenem-relebactam, and comparator agents against contemporary Pseudomonas aeruginosa isolates from United States (US) hospitals. METHODS 3,184 isolates were consecutively collected from 71 US medical… read more here.
Keywords: ceftolozane tazobactam; infection; aeruginosa isolates; ceftazidime avibactam ... See more keywords
In Vitro Activity of Ceftolozane/Tazobactam vs Nonfermenting, Gram-Negative Cystic Fibrosis Isolates
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DOI: 10.1093/ofid/ofy158
Abstract: Abstract Ceftolozane/tazobactam (C/T) was tested and compared against 93 nonfermenting, Gram-negative clinical isolates from cystic fibrosis specimens. Based on current breakpoints for intra-abdominal and urinary tract infections (which may not be appropriate for pulmonary infections),… read more here.
Keywords: tazobactam; nonfermenting gram; cystic fibrosis; gram negative ... See more keywords
556: REAL-WORLD EVALUATION OF CEFTOLOZANE/TAZOBACTAM TREATMENT FOR PSEUDOMONAS ACROSS 253 U.S. HOSPITALS
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DOI: 10.1097/01.ccm.0000551308.61439.70
Abstract: Learning Objectives: Pseudomonas aeruginosa (PsA) is a significant pathogen associated with severe invasive infections requiring early appropriate therapy, particularly in critically ill patients (pts). Ceftolozane/tazobactam (C/T) is an anti-pseudomonal agent indicated for cUTI and cIAI… read more here.
Keywords: early directed; therapy; 556 real; treatment ... See more keywords
Clearance of Piperacillin–Tazobactam and Vancomycin During Continuous Renal Replacement With Regional Citrate Anticoagulation
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DOI: 10.1097/ftd.0000000000001028
Abstract: Background: The use of regional citrate anticoagulation during continuous venovenous hemodiafiltration (CVVHDF) has increased worldwide. However, data on its effect on the pharmacokinetics of antibiotics are limited. In this study, the authors aimed to measure… read more here.
Keywords: piperacillin tazobactam; tazobactam; regional citrate; citrate anticoagulation ... See more keywords
Activity of ceftolozane/tazobactam against Gram-negative isolates among different infections in Hong Kong: SMART 2017-2019.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001487
Abstract: Introduction. Ceftolozane/tazobactam was approved by the Drug Office, Department of Health, Government of the Hong Kong Special Administrative Region in 2017.Hypothesis/Gap Statement. Currently the in vitro activity of ceftolozane/tazobactam against Gram-negative pathogens isolated from patients… read more here.
Keywords: ceftolozane tazobactam; tazobactam; susceptible ceftolozane; piperacillin tazobactam ... See more keywords
Evaluation of Ceftolozane-Tazobactam in Combination with Meropenem against Pseudomonas aeruginosa Sequence Type 175 in a Hollow-Fiber Infection Model
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DOI: 10.1128/aac.00026-18
Abstract: ABSTRACT The aim of this study was to investigate the efficacy of ceftolozane-tazobactam in combination with meropenem against an extensively drug-resistant (XDR) Pseudomonas aeruginosa high-risk clone, sequence type 175, isolated in a Spanish university hospital.… read more here.
Keywords: tazobactam; combination meropenem; ceftolozane tazobactam; tazobactam combination ... See more keywords