LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "tbk1" as a keyword



Photo by almapapi from unsplash

RNF144B inhibits LPS‐induced inflammatory responses via binding TBK1

Sign Up to like & get
recommendations! Published in 2019 at "Journal of Leukocyte Biology"

DOI: 10.1002/jlb.2a0819-055r

Abstract: Innate immune responses need to be precisely controlled to avoid prolonged inflammation and prevent unwanted damage to the host. Here, we report that RNF144B responded dynamically to LPS stimulation and negatively regulated LPS‐induced inflammation. We… read more here.

Keywords: rnf144b inhibits; inhibits lps; tbk1; induced inflammatory ... See more keywords
Photo by bullterriere from unsplash

FBXO11 amplifies type I interferon signaling to exert antiviral effects by facilitating the assemble of TRAF3–TBK1–IRF3 complex

Sign Up to like & get
recommendations! Published in 2023 at "Journal of Medical Virology"

DOI: 10.1002/jmv.28655

Abstract: As the key component of host innate antiviral immunity, type I interferons (IFN‐Is) exert multiple antiviral effects by inducing hundreds of IFN‐stimulated genes. However, the precise mechanism involved in host sensing of IFN‐I signaling priming… read more here.

Keywords: tbk1; ifn signaling; traf3; tbk1 irf3 ... See more keywords

Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration

Sign Up to like & get
recommendations! Published in 2021 at "Molecular Neurobiology"

DOI: 10.1007/s12035-020-02235-3

Abstract: Background TANK-binding kinase1 (TBK1) haploinsufficiency has been shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, the mechanism is unclear. Methods Myeloid Tbk1 knockout mice (Tbk1-LKO mice) were established and motor… read more here.

Keywords: infiltration; myeloid tbk1; tbk1; inflammatory ... See more keywords
Photo by lensshooter from unsplash

Functional characterization of duck TBK1 in IFN‐&bgr; induction

Sign Up to like & get
recommendations! Published in 2018 at "Cytokine"

DOI: 10.1016/j.cyto.2018.09.007

Abstract: HighlightsduTBK1 is ubiquitously expressed in various duck tissues.duTBK1 contributes to the type I IFN induction via the activation of IRF1 and NF‐&kgr;B.The kinase domain and ubiquitin‐like domain of duTBK1 are essential for IFN‐&bgr; induction.Overexpression of… read more here.

Keywords: ifn bgr; bgr induction; dutbk1; tbk1 ... See more keywords
Photo from wikipedia

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation.

Sign Up to like & get
recommendations! Published in 2019 at "Developmental cell"

DOI: 10.1016/j.devcel.2019.01.027

Abstract: Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here, we report that Stx17 functions in assembly of protein complexes during autophagy initiation. Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls the formation of the… read more here.

Keywords: tbk1; atg13 fip200; autophagy initiation; syntaxin ... See more keywords
Photo by ca_tran from unsplash

TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis.

Sign Up to like & get
recommendations! Published in 2018 at "Journal of autoimmunity"

DOI: 10.1016/j.jaut.2018.02.001

Abstract: OBJECTIVE Upregulation of type I interferons (IFN-I) is a hallmark of systemic autoimmune diseases like primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Expression of IFN-I is induced by three different… read more here.

Keywords: gren syndrome; ssc; systemic lupus; treatment ... See more keywords
Photo from wikipedia

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

Sign Up to like & get
recommendations! Published in 2018 at "Neurobiology of Aging"

DOI: 10.1016/j.neurobiolaging.2018.06.015

Abstract: Mutations in TANK binding kinase 1 (TBK1) have been linked to amyotrophic lateral sclerosis. Some TBK1 variants are nonsense and are predicted to cause disease through haploinsufficiency; however, many other mutations are missense with unknown… read more here.

Keywords: als associated; kinase; tbk1 mutations; tbk1 ... See more keywords
Photo from wikipedia

TBK1 variants in Chinese patients with amyotrophic lateral sclerosis

Sign Up to like & get
recommendations! Published in 2021 at "Neurobiology of Aging"

DOI: 10.1016/j.neurobiolaging.2020.07.028

Abstract: TBK1 has been reported as a risk gene of amyotrophic lateral sclerosis (ALS). We screened TBK1 variants in 69 familial ALS patients and 608 sporadic ALS patients from mainland China. All 20 coding exons and… read more here.

Keywords: tbk1 variants; tbk1; amyotrophic lateral; als patients ... See more keywords
Photo by nci from unsplash

Dual TBK1/IKKɛ inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro.

Sign Up to like & get
recommendations! Published in 2020 at "Toxicology"

DOI: 10.1016/j.tox.2020.152579

Abstract: The common causes of Non-alcoholic fatty liver disease (NAFLD) are obesity, dyslipidemia, and insulin resistance. Metabolic disorders and lipotoxic hepatocyte damage are hallmarks of NAFLD. Even though amlexanox, a dual inhibitor of TRAF associated nuclear… read more here.

Keywords: palmitic acid; treatment; tbk1; hepatotoxicity ... See more keywords
Photo by diana_pole from unsplash

Discovery of BAY-985 a highly selective TBK1/Ikkε inhibitor.

Sign Up to like & get
recommendations! Published in 2019 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.9b01460

Abstract: . The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKKε are non-canonical members of the inhibitor of nuclear factor κB (IκB) kinase family. These kinases play important roles in multiple cellular pathways and,… read more here.

Keywords: highly selective; tbk1; bay 985; tbk1 ikk ... See more keywords
Photo by neom from unsplash

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor.

Sign Up to like & get
recommendations! Published in 2019 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.9b00027

Abstract: The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and neuroinflammation. Herein, we report the… read more here.

Keywords: tbk1 inhibitor; highly selective; discovery gsk8612; tbk1 ... See more keywords