Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration
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DOI: 10.1007/s12035-020-02235-3
Abstract: Background TANK-binding kinase1 (TBK1) haploinsufficiency has been shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, the mechanism is unclear. Methods Myeloid Tbk1 knockout mice (Tbk1-LKO mice) were established and motor… read more here.
Keywords: infiltration; myeloid tbk1; tbk1; inflammatory ... See more keywords