DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.029
Abstract: DExD/H-box helicase members are key receptors for recognizing viral nucleic acids, and they regulate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated type I interferon (IFN) production. Here, we report that the DExD/H-box helicase family member DExD/H-box… read more here.
Keywords: ddx19; ifn production; tbk1 ikk; production ... See more keywords
Dual TBK1/IKKɛ inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152579
Abstract: The common causes of Non-alcoholic fatty liver disease (NAFLD) are obesity, dyslipidemia, and insulin resistance. Metabolic disorders and lipotoxic hepatocyte damage are hallmarks of NAFLD. Even though amlexanox, a dual inhibitor of TRAF associated nuclear… read more here.
Keywords: palmitic acid; treatment; tbk1; hepatotoxicity ... See more keywords
Discovery of BAY-985 a highly selective TBK1/Ikkε inhibitor.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01460
Abstract: . The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKKε are non-canonical members of the inhibitor of nuclear factor κB (IκB) kinase family. These kinases play important roles in multiple cellular pathways and,… read more here.
Keywords: highly selective; tbk1; bay 985; tbk1 ikk ... See more keywords
TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
Sign Up to like & getrecommendations! Published in 2018 at "Nature cell biology"
DOI: 10.1038/s41556-018-0229-6
Abstract: The linear-ubiquitin chain assembly complex (LUBAC) modulates signalling via various immune receptors. In tumour necrosis factor (TNF) signalling, linear (also known as M1) ubiquitin enables full gene activation and prevents cell death. However, the mechanisms… read more here.
Keywords: tnf induced; tbk1 ikk; cell death;
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abh0068
Abstract: Description ID2 reduces the interferon response to viral infections by inhibiting the activation of IRF3. ID2 interferes with IRF3 activation Inhibitor of DNA binding protein 2 (ID2) controls the development and differentiation of various immune… read more here.
Keywords: id2; infection; tbk1 ikk; irf3 ... See more keywords
A novel TBK1/IKKϵ is involved in immune response and interacts with MyD88 and MAVS in the scallop Chlamys farreri
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1091419
Abstract: Inhibitor of κB kinase (IKK) family proteins are key signaling molecules in the animal innate immune system and are considered master regulators of inflammation and innate immunity that act by controlling the activation of transcription… read more here.
Keywords: chlamys farreri; tbk1 ikk; scallop chlamys; cfikk3 ... See more keywords