Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00027
Abstract: The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and neuroinflammation. Herein, we report the… read more here.
Keywords: tbk1 inhibitor; highly selective; discovery gsk8612; tbk1 ... See more keywords
TBK1 and IRF3 are potential therapeutic targets in Enterovirus A71-associated diseases
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0011001
Abstract: Background Enterovirus A71 (EV-A71) is an important causative agent of hand-foot-and-mouth disease (HFMD) associated with enormous healthcare and socioeconomic burden. Although a range of studies about EV-A71 pathogenesis have been well described, the underlying molecular… read more here.
Keywords: a71 induced; tbk1 inhibitor; tbk1 irf3; irf3 agonist ... See more keywords
TBK1 inhibitor amlexanox exerts anti-cancer effects against endometrial cancer by regulating AKT/NF-κB signaling
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DOI: 10.7150/ijbs.100212
Abstract: Endometrial cancer, a common gynecological malignancy, poses significant clinical challenges, particularly in advanced or recurrent cases. TANK-binding kinase 1 (TBK1), a serine/threonine kinase, plays crucial roles in inflammation and immunity by activating nuclear factor (NF)-κB… read more here.
Keywords: cancer; tbk1 inhibitor; anti cancer; endometrial cancer ... See more keywords