Recent progress in small molecule TBK1 inhibitors: a patent review (2015– 2020)
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2021.1904893
Abstract: ABSTRACT Introduction: TANK-binding kinase 1 (TBK1) is a key mediator of innate immunity processes and studies have reported on its role in inflammatory and autoimmune diseases. Moreover, several studies have also described the important role… read more here.
Keywords: 2015 2020; small molecule; tbk1; tbk1 inhibitors ... See more keywords
Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2076674
Abstract: sABSTRACT TANK-binding kinase 1 (TBK1), a noncanonical member of the inhibitor-kappaB kinases (IKKs) family, plays a vital role in coordinating the signalling pathways of innate immunity, involving in the process of neuroinflammation, autophagy, and oncogenesis.… read more here.
Keywords: tbk1; pyrazolo pyridine; tbk1 inhibitors; pyridine derivatives ... See more keywords