FBXO11 amplifies type I interferon signaling to exert antiviral effects by facilitating the assemble of TRAF3–TBK1–IRF3 complex
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28655
Abstract: As the key component of host innate antiviral immunity, type I interferons (IFN‐Is) exert multiple antiviral effects by inducing hundreds of IFN‐stimulated genes. However, the precise mechanism involved in host sensing of IFN‐I signaling priming… read more here.
Keywords: tbk1; ifn signaling; traf3; tbk1 irf3 ... See more keywords
Combination of mesenchymal stem cells and FK506 prolongs heart allograft survival by inhibiting TBK1/IRF3-regulated-IFN-γ production.
Sign Up to like & getrecommendations! Published in 2021 at "Immunology letters"
DOI: 10.1016/j.imlet.2021.06.007
Abstract: Lifelong immunosuppression use presents many serious side effects to transplant recipients. Previous studies have shown that mesenchymal stem cells (MSC) regulate the progress of inflammation and protect allograft function. However, the benefits of MSC combined… read more here.
Keywords: heart; ifn production; tbk1 irf3; stem cells ... See more keywords
TBK1 and IRF3 are potential therapeutic targets in Enterovirus A71-associated diseases
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0011001
Abstract: Background Enterovirus A71 (EV-A71) is an important causative agent of hand-foot-and-mouth disease (HFMD) associated with enormous healthcare and socioeconomic burden. Although a range of studies about EV-A71 pathogenesis have been well described, the underlying molecular… read more here.
Keywords: a71 induced; tbk1 inhibitor; tbk1 irf3; irf3 agonist ... See more keywords
Palmitic Acid Promotes Virus Replication in Fish Cell by Modulating Autophagy Flux and TBK1-IRF3/7 Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01764
Abstract: Palmitic acid is the most common saturated fatty acid in animals, plants, and microorganisms. Studies highlighted that palmitic acid plays a significant role in diverse cellular processes and viral infections. Accumulation of palmitic acid was… read more here.
Keywords: palmitic acid; tbk1 irf3; virus replication; acid ... See more keywords
The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1093212
Abstract: Cystic fibrosis (CF) is a rare autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The most common mutation is F508del-CFTR (ΔF) which leads the encoded ion channel towards… read more here.
Keywords: sting tbk1; sting pathway; ifn; tbk1 irf3 ... See more keywords