ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function
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DOI: 10.1016/j.neurobiolaging.2018.06.015
Abstract: Mutations in TANK binding kinase 1 (TBK1) have been linked to amyotrophic lateral sclerosis. Some TBK1 variants are nonsense and are predicted to cause disease through haploinsufficiency; however, many other mutations are missense with unknown… read more here.
Keywords: als associated; kinase; tbk1 mutations; tbk1 ... See more keywords