Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation.
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DOI: 10.1016/j.phrs.2021.105679
Abstract: Sorting nexin 10 (SNX10) has been reported as a critical regulator in macrophage function, and germline SNX10 knockout effectively alleviated mouse colitis. Here, we investigated the precise role of SNX10 in inflammatory responses in macrophages… read more here.
Keywords: pikfyve; mouse colitis; tbk1 rel; rel signaling ... See more keywords