One-step construction of molecular complexity by tert-butyl nitrite (TBN)-initiated cascade α,β-sp3 C-H bond difunctionalization and C-N bond cleavage.
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DOI: 10.1039/c8cc06946h
Abstract: TBN-initiated cascade multifunctionalization of inert C-H and C-N bonds in N-arylazacycles has been realized under transition-metal free conditions, in which the synthetically useful oxime, N-NO and aldehyde functional groups were constructed in only one synthetic… read more here.
Keywords: bond; tbn initiated; one step; initiated cascade ... See more keywords
Oxidative Desymmetrization of Isoindolines Realized by tert-Butyl Nitrite (TBN) Initiated Radical sp3 C–H Activation Relay (CHAR)
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DOI: 10.1055/s-0040-1706010
Abstract: An oxidative desymmetrization of isoindolines was realized by TBN initiated radical sp3 C–H activation relay (CHAR), providing a series of ω-hydroxylactams in high yields. This reaction exhibits broad substrate scope and functional group tolerance, and… read more here.
Keywords: initiated radical; desymmetrization isoindolines; oxidative desymmetrization; desymmetrization ... See more keywords