Loss of CXCL12/CXCR4 signalling impacts several aspects of cardiovascular development but does not exacerbate Tbx1 haploinsufficiency
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DOI: 10.1371/journal.pone.0207251
Abstract: The CXCL12-CXCR4 pathway has crucial roles in stem cell homing and maintenance, neuronal guidance, cancer progression, inflammation, remote-conditioning, cell migration and development. Recently, work in chick suggested that signalling via CXCR4 in neural crest cells… read more here.
Keywords: cxcl12 cxcr4; tbx1; cxcl12; tbx1 haploinsufficiency ... See more keywords