Plasma Exosomes Derived from Patients with Primary Immune Thrombocytopenia Attenuate TBX21+ Regulatory T Cell-Mediated Immune Suppression via MiR-363-3p
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DOI: 10.1007/s10753-025-02275-8
Abstract: Primary Immune Thrombocytopenia (ITP) is characterized by reduced immunosuppressive function of regulatory T cells (Tregs), contributing to immune imbalance and decreased platelet counts. However, the mechanisms behind this reduced efficacy of Tregs remain unclear. Our… read more here.
Keywords: spi1 tbx21; primary immune; immune thrombocytopenia; cell ... See more keywords
DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T-cells in PTCL-NOS.
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DOI: 10.1182/blood.2021015019
Abstract: Peripheral T-cell lymphomas (PTCLs) are heterogenous T-cell neoplasms often associated with epigenetic dysregulation. We investigated de novo DNA methyltransferase 3A (DNMT3A) mutations in common PTCL entities, including angioimmunoblastic T-cell lymphoma and novel molecular subtypes identified… read more here.
Keywords: cell; tbx21; dnmt3a; ptcl nos ... See more keywords
TBX21 Methylation as a Potential Regulator of Immune Suppression in CMS1 Subtype Colorectal Cancer
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DOI: 10.3390/cancers14194594
Abstract: Simple Summary Cytotoxic T lymphocytes (CTL) are critical for response to therapy and survival in CRC. Additionally, CTL are required for response to immune checkpoint inhibitor (ICI) therapy which does not work for most CRC… read more here.
Keywords: crc; methylation; tbx21; ctl function ... See more keywords