Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145322
Abstract: Abstract T-box 5 (TBX5) protein belongs to the T-box family whose members play a crucial role in cell-type specification, morphogenesis and organogenesis. TBX5 is a transcription factor important for cardiac development and upper limbs formation… read more here.
Keywords: promoter region; transcription; tbx5; box ... See more keywords
A TBX5 3′UTR variant increases the risk of congenital heart disease in the Han Chinese population
Sign Up to like & getrecommendations! Published in 2017 at "Cell Discovery"
DOI: 10.1038/celldisc.2017.26
Abstract: TBX5 is a vital transcription factor involved in cardiac development in a dosage-dependent manner. But little is known about the potential association of TBX5 3′ untranslated region (UTR) variations with congenital cardiac malformations. This study… read more here.
Keywords: tbx5; risk congenital; han chinese; tbx5 utr ... See more keywords
Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180003
Abstract: Synoviocytes from rheumatoid arthritis (RA) patients share certain features with tumor cells, such as over proliferation and invasion. Anomalous microRNA (miRNA) expression may participate in the pathogenesis of RA in different ways. The objective of… read more here.
Keywords: tbx5; apoptosis; proliferation; mir 10a ... See more keywords
Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control
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DOI: 10.1093/cvr/cvaa239
Abstract: Abstract Aims Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction… read more here.
Keywords: arrhythmia; tbx5; control; preclinical evidence ... See more keywords
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility
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DOI: 10.1101/2022.05.14.491627
Abstract: Heart development and rhythm control are highly Tbx5 dosage-sensitive. TBX5 haploinsufficiency causes congenital conduction disorders, whereas increased expression levels of TBX5 in human heart samples has been associated with atrial fibrillation. We deleted the conserved… read more here.
Keywords: tbx5; expression; susceptibility; regulatory region ... See more keywords
microRNA-10a Targets T-box 5 to Inhibit the Development of Cardiac Hypertrophy.
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DOI: 10.1536/ihj.16-020
Abstract: The mechanism of cardiac hypertrophy involving microRNAs (miRNAs) is attracting increasing attention. Our study aimed to investigate the role of miR-10a in cardiac hypertrophy development and the underlying regulatory mechanism.Transverse abdominal aortic constriction (TAAC) surgery… read more here.
Keywords: cardiac hypertrophy; tbx5; microrna 10a; hypertrophy ... See more keywords
A New TBX5 Loss-of-Function Mutation Contributes to Congenital Heart Defect and Atrioventricular Block.
Sign Up to like & getrecommendations! Published in 2020 at "International heart journal"
DOI: 10.1536/ihj.19-650
Abstract: Congenital heart defect (CHD) represents the most common birth deformity, afflicting 1% of all births worldwide, and accounts for substantial morbidity and mortality. Increasing evidence highlights the pivotal roles of genetic etiologies in the pathogenesis… read more here.
Keywords: tbx5; heart; chd; defect ... See more keywords