Tbx15/18/22 shares a binding site with Tbx6-r.b to maintain expression of a muscle structural gene in ascidian late embryos.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.12.012
Abstract: The ascidian larval tail contains muscle cells for swimming. Most of these muscle cells differentiate autonomously. The genetic program behind this autonomy has been studied extensively and the genetic cascade from maternal factors to initiation… read more here.
Keywords: expression; embryos; muscle; muscle structural ... See more keywords
Bi-allelic loss of function variants of TBX6 causes a spectrum of malformation of spine and rib including congenital scoliosis and spondylocostal dysostosis
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DOI: 10.1136/jmedgenet-2018-105920
Abstract: Background Congenital scoliosis (CS) is a common vertebral malformation. Spondylocostal dysostosis (SCD) is a rare skeletal dysplasia characterised by multiple vertebral malformations and rib anomalies. In a previous study, a compound heterozygosity for a null… read more here.
Keywords: congenital scoliosis; spondylocostal dysostosis; missense variants; tbx6 ... See more keywords
Functionally distinct roles for T and Tbx6 during mouse development
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DOI: 10.1242/bio.054692
Abstract: ABSTRACT The mouse T-box transcription factors T and Tbx6 are co-expressed in the primitive streak and have unique domains of expression; T is expressed in the notochord, while Tbx6 is expressed in the presomitic mesoderm.… read more here.
Keywords: show; tbx6; dna binding; domain ... See more keywords
Molecular identification of T-box transcription factor 6 and prognostic assessment in patients with congenital scoliosis: A single-center study
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DOI: 10.3389/fmed.2022.941468
Abstract: Background Congenital scoliosis (CS) is characterized by vertebral malformations. The precise etiology of CS is not fully defined. A compound inheritance of TBX6 was identified in 10% of patients with CS in Han Chinese and… read more here.
Keywords: congenital scoliosis; scoliosis; tacs; identification box ... See more keywords