Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202502146
Abstract: FAT atypical cadherin 1 (FAT1) is one of the most frequently mutated genes in head and neck squamous cell carcinoma (HNSCC), exhibiting the highest mutation rate across different tumor types. Although FAT1's role has attracted… read more here.
Keywords: fat1; acid oxidation; cpt1a dependent; tca cycle ... See more keywords
Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31313
Abstract: Genetic alterations drive metabolic reprograming to meet increased biosynthetic precursor and energy demands for cancer cell proliferation and survival in unfavorable environments. A systematic study of gene‐metabolite regulatory networks and metabolic dysregulation should reveal the… read more here.
Keywords: dysregulation; tricarboxylic acid; prostate cancer; cycle ... See more keywords
Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a1119-236r
Abstract: The pyruvate dehydrogenase complex (PDC)/pyruvate dehydrogenase kinase (PDK) axis directs the universal survival principles of immune resistance and tolerance in monocytes by controlling anabolic and catabolic energetics. Immune resistance shifts to immune tolerance during inflammatory… read more here.
Keywords: tca cycle; cycle; dehydrogenase complex; pyruvate dehydrogenase ... See more keywords
Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2371-0
Abstract: Acetaminophen (APAP) is one of the most commonly used analgesics worldwide, and overdoses are associated with lactic acidosis, hepatocyte toxicity, and acute liver failure due to oxidative stress and mitochondrial dysfunction. Hepatoma cell lines typically… read more here.
Keywords: glycolysis; production; hepg2 cells; tca cycle ... See more keywords
TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurovirology"
DOI: 10.1007/s13365-021-00970-4
Abstract: In the brain, both HIV-1 and methamphetamine (meth) use result in increases in oxidative and nitrosative stress. This redox stress is thought to contribute to the pathogenesis of HIV-associated neurocognitive disorder (HAND) and further worsening… read more here.
Keywords: use; neurocognitive disorder; hiv; tca cycle ... See more keywords
Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.11.005
Abstract: Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major… read more here.
Keywords: lactate oxidation; want lactate; waste; tca cycle ... See more keywords
TCA cycle signalling and the evolution of eukaryotes.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.09.014
Abstract: A major question remaining in the field of evolutionary biology is how prokaryotic organisms made the leap to complex eukaryotic life. The prevailing theory depicts the origin of eukaryotic cell complexity as emerging from the… read more here.
Keywords: signalling evolution; cycle; cycle signalling; biology ... See more keywords
NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101116
Abstract: Summary Many metabolic diseases disrupt endoplasmic reticulum (ER) homeostasis, but little is known about how metabolic activity is communicated to the ER. Here, we show in hepatocytes and other metabolically active cells that decreasing the… read more here.
Keywords: reticulum homeostasis; endoplasmic reticulum; tca cycle; activity ... See more keywords
Two mitochondrial phosphatases, PP2c63 and Sal2, are required for posttranslational regulation of the TCA cycle in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular plant"
DOI: 10.1016/j.molp.2021.03.023
Abstract: Protein phosphorylation is a well-established post-translational mechanism that regulates protein functions and metabolic pathways. It is known that several plant mitochondrial proteins are phosphorylated in a reversible manner. However, the identity of the protein kinases/phosphatases… read more here.
Keywords: protein; regulation tca; cycle; tca cycle ... See more keywords
Phosphatases are involved in modulating the TCA cycle in plants.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular plant"
DOI: 10.1016/j.molp.2021.05.019
Abstract: Phosphorylation is a reversible posttranslational modification that modulates the activities of numerous proteins. In plants, it is known that several mitochondrial proteins can be phosphorylated, including enzymes of the TCA cycle. The kinases and phosphorylases… read more here.
Keywords: phosphatases involved; phosphorylation; cycle; tca cycle ... See more keywords
The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2016.11.008
Abstract: Abstract Tyrphostin 23 (T23) is a well‐known inhibitor of protein tyrosine kinases and has been considered as potential anti‐cancer drug. T23 was recently reported to acutely stimulate the glycolytic flux in primary cultured astrocytes. To… read more here.
Keywords: tricarboxylic acid; protein tyrosine; cycle; strongly accelerated ... See more keywords