An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve‐agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions
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DOI: 10.1016/j.freeradbiomed.2018.10.425
Abstract: ABSTRACT We have recently shown that the pyridinium aldoximes, best‐known as therapeutic antidotes for chemical warfare nerve‐agents, could markedly detoxify the carcinogenic tetrachloro‐1,4‐benzoquinone (TCBQ) via an unusual double Beckmann fragmentation mechanism. However, it is still… read more here.
Keywords: radical homolysis; tcbq; iminyl radical; normal physiological ... See more keywords