Differential effects of Clostridium difficile toxins on ion secretion and cell integrity in human intestinal cells
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0365-0
Abstract: BackgroundToxin A (TcdA), toxin B (TcdB), and binary toxin (CDT) produced by Clostridium difficile (CD) are thought to play a key role in inducing diarrhea. The aim of this study was to investigate the individual… read more here.
Keywords: clostridium difficile; secretion; tcda; intestinal cells ... See more keywords
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature microbiology"
DOI: 10.1038/s41564-019-0464-z
Abstract: Clostridium difficile toxin A (TcdA) is a major exotoxin contributing to disruption of the colonic epithelium during C. difficile infection. TcdA contains a carbohydrate-binding combined repetitive oligopeptides (CROPs) domain that mediates its attachment to cell… read more here.
Keywords: clostridium difficile; tcda; low density; difficile toxin ... See more keywords
Esculin hydrolysis negative and TcdA-only producing strains of Clostridium (Clostridiodes) difficile from the environment in Western Australia.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of applied microbiology"
DOI: 10.1111/jam.15500
Abstract: BACKGROUND AND AIMS Clostridium (Clostridiodes) difficile clade 3 ribotype (RT) 023 strains that fail to produce black colonies on bioMérieux ChromID agar have been reported, as well as variant strains of C. difficile that produce… read more here.
Keywords: environment western; tcda; clostridiodes difficile; strains difficile ... See more keywords
Structure and conformational dynamics of Clostridioides difficile toxin A
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DOI: 10.26508/lsa.202201383
Abstract: This study presents a complete structural model of TcdA holotoxin and sheds new lights into the conformational dynamics of TcdA and its roles in TcdA intoxication. Clostridioides difficile toxin A and B (TcdA and TcdB)… read more here.
Keywords: difficile toxin; structure; clostridioides difficile; tcda ... See more keywords
Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.03078
Abstract: Clostridioides difficile toxin A (TcdA) and Toxin B (TcdB) trigger inflammasome activation with caspase-1 activation in cultured cells, which in turn induce the release of IL-6, IFN-γ, and IL-8. Release of these proinflammatory responses is… read more here.
Keywords: ras subtype; tcda; glucosylation; toxin ... See more keywords