Follicular helper and follicular cytotoxic T cells in primary Sjögren’s Syndrome: clues for an abnormal antiviral response as a pathogenic mechanism
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Medicine"
DOI: 10.1080/07853890.2018.1561890
Abstract: Introduction: In chronic viral infections, T follicular helper (Tfh) cells are crucial to sustain CD8 cytotoxic T cells in face of the persistence of viral antigens. Moreover, the usual Th1 profile that is associated with… read more here.
Keywords: cytotoxic cells; pss; disease; pss patients ... See more keywords
Lymphoid tissue residency: A key to understand Tcf-1+PD-1+ T cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1074698
Abstract: During chronic antigen exposure, a subset of exhausted CD8+ T cells differentiate into stem cell-like or progenitor-like T cells expressing both transcription factor Tcf-1 (T cell factor-1) and co-inhibitory receptor PD-1. These Tcf-1+ stem-like or… read more here.
Keywords: lymphoid tissue; tcf; tissue residency; tcf cells ... See more keywords