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   Articles with "tcf lef" as a keyword



Synthesis of Unsymmetrical Squaramides as Allosteric GSK‐3β Inhibitors Promoting β‐Catenin‐Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells

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recommendations! Published in 2022 at "ChemMedChem"

DOI: 10.1002/cmdc.202200456

Abstract: The glycogen synthase kinase 3β (GSK‐3β) is a ubiquitous enzyme that is a validated target for the development of potential therapeutics useful in several diseases including retinal degeneration. Aiming at developing an innovative class of… read more here.

Keywords: epithelial cells; pigment epithelial; retinal pigment; tcf lef ... See more keywords

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109705

Abstract: Mouse embryonic stem cells (mESCs) can be maintained in vitro in defined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory factor (LIF), which act synergistically to promote… read more here.

Keywords: tcf lef; topologically associated; associated domain; exit pluripotent ... See more keywords

A Reciprocal Interaction between β-Catenin and Osterix in Cementogenesis

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-08607-5

Abstract: Although accumulating evidence indicates that both β-catenin and osterix (Osx) are essential for bone and tooth development, few studies have investigated the interaction of these two key proteins in the context of cementogenesis. In this… read more here.

Keywords: tcf lef; cementogenesis; catenin; constitutively active ... See more keywords

WNT-mediating TCF/LEF transcription factor gene expression in early human pluripotency and cell lineages differs from the rodent paradigm

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recommendations! Published in 2025 at "Journal of Cell Science"

DOI: 10.1242/jcs.264257

Abstract: ABSTRACT Embryonic stem (ES) cell research has uncovered different requirements for WNT/β-catenin signalling in human naïve pluripotent cells compared to the mouse paradigm. It is therefore important to study WNT/β-catenin signalling directly in models that… read more here.

Keywords: cell; wnt catenin; tcf lef; early human ... See more keywords

Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis

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recommendations! Published in 2018 at "International Journal of Medical Sciences"

DOI: 10.7150/ijms.26741

Abstract: Bone formation occurs by two distinct mechanisms, namely, periosteal ossification and endochondral ossification. In both mechanisms, osteoblasts play an important role in the secretion and mineralization of bone-specific extracellular matrix. Differentiation and maturation of osteoblasts… read more here.

Keywords: tcf lef; bone; role; osteogenesis ... See more keywords