Synthesis of Unsymmetrical Squaramides as Allosteric GSK‐3β Inhibitors Promoting β‐Catenin‐Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells
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DOI: 10.1002/cmdc.202200456
Abstract: The glycogen synthase kinase 3β (GSK‐3β) is a ubiquitous enzyme that is a validated target for the development of potential therapeutics useful in several diseases including retinal degeneration. Aiming at developing an innovative class of… read more here.
Keywords: epithelial cells; pigment epithelial; retinal pigment; tcf lef ... See more keywords
TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.
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DOI: 10.1016/j.celrep.2021.109705
Abstract: Mouse embryonic stem cells (mESCs) can be maintained in vitro in defined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory factor (LIF), which act synergistically to promote… read more here.
Keywords: tcf lef; topologically associated; associated domain; exit pluripotent ... See more keywords
A Reciprocal Interaction between β-Catenin and Osterix in Cementogenesis
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DOI: 10.1038/s41598-017-08607-5
Abstract: Although accumulating evidence indicates that both β-catenin and osterix (Osx) are essential for bone and tooth development, few studies have investigated the interaction of these two key proteins in the context of cementogenesis. In this… read more here.
Keywords: tcf lef; cementogenesis; catenin; constitutively active ... See more keywords
Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis
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DOI: 10.7150/ijms.26741
Abstract: Bone formation occurs by two distinct mechanisms, namely, periosteal ossification and endochondral ossification. In both mechanisms, osteoblasts play an important role in the secretion and mineralization of bone-specific extracellular matrix. Differentiation and maturation of osteoblasts… read more here.
Keywords: tcf lef; bone; role; osteogenesis ... See more keywords