Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition
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DOI: 10.1042/bsr20180393
Abstract: Protein degradation is essential to compensate for the damaging effects of proteotoxic stress. To ensure protein and redox homeostasis in response to proteasome inhibition, the cleavage and nuclear translocation of the endoplasmic reticulum (ER)-bound transcription… read more here.
Keywords: proteasome inhibition; tcf11 nrf1; calpain; activation ... See more keywords