Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG‐ALL‐2015: A multicenter study
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DOI: 10.1002/cncr.34741
Abstract: Contemporary risk‐directed treatment has improved the outcome of patients with acute lymphoblastic leukemia (ALL) and TCF3::PBX1 fusion. In this study, the authors seek to identify prognostic factors that can be used to further improve outcome. read more here.
Keywords: prognostic factors; leukemia tcf3; acute lymphoblastic; lymphoblastic leukemia ... See more keywords
Co-occurrence of TCF3-PBX1 gene fusion, and chromosomal aberration in a pediatric pre-B cell acute lymphoblastic leukemia with clitoris swelling
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DOI: 10.1097/md.0000000000024802
Abstract: Abstract Rationale: Clitoris swelling as the initial clinical presentation of acute lymphoblastic leukemia (ALL) is extremely rare. These patients may be misdiagnosed with acute myeloid leukemia or solid tumor, and the main treatment can also… read more here.
Keywords: clitoris; acute lymphoblastic; clitoris swelling; tcf3 pbx1 ... See more keywords
Extended vincristine and dexamethasone pulse therapy may not be necessary for children with TCF3‐PBX1 positive acute lymphoblastic leukaemia
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DOI: 10.1111/bjh.18437
Abstract: The effect of prolonged pulse therapy with vincristine and dexamethasone (VD) during maintenance therapy on the outcome of paediatric patients with TCF3‐PBX1 positive acute lymphoblastic leukaemia (ALL) remains uncertain. We conducted non‐inferiority analysis of 263… read more here.
Keywords: year; vincristine dexamethasone; pbx1 positive; pulse therapy ... See more keywords
Determination of the Origin of the t(1;19) TCF3-PBX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)
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DOI: 10.1182/blood-2018-99-110521
Abstract: Pediatric acute lymphoblastic leukemia (ALL) is characterized by recurrent chromosomal translocations. The translocation t(1;19) that fuses the gene encoding the basic helix-loop-helix transcription factor TCF3 with the gene encoding the homeodomain protein PBX1 is the… read more here.
Keywords: fusion; pbx1; pcr; translocation ... See more keywords
NKX6-3 in B-Cell Progenitor Differentiation and Leukemia
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DOI: 10.3390/genes16101199
Abstract: Early B-cell development is primarily regulated at the transcriptional level and comprises the consecutive differentiation stages B-cell progenitor, pro-B-cell and pre-B-cell. These entities provide the cells of origin in B-cell precursor acute lymphoid leukemia (BCP-ALL)… read more here.
Keywords: differentiation; cell progenitor; bcp; cell ... See more keywords
Association of Multiple Clefts Nuclei in Blasts with TCF3::PBX1 Fusion in B-Lymphoblastic Leukemia/Lymphoma.
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DOI: 10.7754/clin.lab.2024.240904
Abstract: BACKGROUND Several particular kinds of typical morphology characteristics of leukemic blasts associated with the specific subtypes of leukemia have been reported. However, B acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) has rarely been reported. The purpose of this… read more here.
Keywords: pbx1 fusion; nuclei blasts; tcf3 pbx1; clefts nuclei ... See more keywords