Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG‐ALL‐2015: A multicenter study
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DOI: 10.1002/cncr.34741
Abstract: Contemporary risk‐directed treatment has improved the outcome of patients with acute lymphoblastic leukemia (ALL) and TCF3::PBX1 fusion. In this study, the authors seek to identify prognostic factors that can be used to further improve outcome. read more here.
Keywords: prognostic factors; leukemia tcf3; acute lymphoblastic; lymphoblastic leukemia ... See more keywords
Co-occurrence of TCF3-PBX1 gene fusion, and chromosomal aberration in a pediatric pre-B cell acute lymphoblastic leukemia with clitoris swelling
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DOI: 10.1097/md.0000000000024802
Abstract: Abstract Rationale: Clitoris swelling as the initial clinical presentation of acute lymphoblastic leukemia (ALL) is extremely rare. These patients may be misdiagnosed with acute myeloid leukemia or solid tumor, and the main treatment can also… read more here.
Keywords: clitoris; acute lymphoblastic; clitoris swelling; tcf3 pbx1 ... See more keywords
Extended vincristine and dexamethasone pulse therapy may not be necessary for children with TCF3‐PBX1 positive acute lymphoblastic leukaemia
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DOI: 10.1111/bjh.18437
Abstract: The effect of prolonged pulse therapy with vincristine and dexamethasone (VD) during maintenance therapy on the outcome of paediatric patients with TCF3‐PBX1 positive acute lymphoblastic leukaemia (ALL) remains uncertain. We conducted non‐inferiority analysis of 263… read more here.
Keywords: year; vincristine dexamethasone; pbx1 positive; pulse therapy ... See more keywords
Determination of the Origin of the t(1;19) TCF3-PBX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)
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DOI: 10.1182/blood-2018-99-110521
Abstract: Pediatric acute lymphoblastic leukemia (ALL) is characterized by recurrent chromosomal translocations. The translocation t(1;19) that fuses the gene encoding the basic helix-loop-helix transcription factor TCF3 with the gene encoding the homeodomain protein PBX1 is the… read more here.
Keywords: fusion; pbx1; pcr; translocation ... See more keywords