Kindlin-2–miR-1258–TCF4 feedback loop promotes hepatocellular carcinoma invasion and metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-022-01866-8
Abstract: Upregulated Kindlin-2 expression in hepatocellular carcinoma (HCC) correlates with metastasis and poor prognosis. In this study, we investigated the molecular mechanism of Kindlin-2 in HCC. Kindlin-2 downstream pathways were explored through microRNA sequencing. The Kindlin-2–miR-1258–TCF4… read more here.
Keywords: expression; mir 1258; kindlin mir; kindlin ... See more keywords
TCF4 promotes colorectal cancer drug resistance and stemness via regulating ZEB1/ZEB2 expression
Sign Up to like & getrecommendations! Published in 2020 at "Protoplasma"
DOI: 10.1007/s00709-020-01480-6
Abstract: The present study aims to investigate the roles of TCF4 and its underlying mechanism in colorectal cancer (CRC). Doxorubicin-resistant DLD-1 (DLD1 DR), TCF4 overexpression, and TCF4 knockdown cell lines were constructed. A flow cytometer was… read more here.
Keywords: tcf4; zeb1 zeb2; resistance; doxorubicin ... See more keywords
Impairment of different protein domains causes variable clinical presentation within Pitt-Hopkins syndrome and suggests intragenic molecular syndromology of TCF4.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2017.08.004
Abstract: Pitt-Hopkins syndrome is a neurodevelopmental disorder characterized by severe intellectual disability and a distinctive facial gestalt. It is caused by haploinsufficiency of the TCF4 gene. The TCF4 protein has different functional domains, with the NLS… read more here.
Keywords: pitt hopkins; molecular syndromology; tcf4; hopkins syndrome ... See more keywords
Isoform‐Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2016.11.006
Abstract: &NA; The cell fate decision between interferon‐producing plasmacytoid DC (pDC) and antigen‐presenting classical DC (cDC) is controlled by the E protein transcription factor TCF4 (E2‐2). We report that TCF4 comprises two transcriptional isoforms, both of… read more here.
Keywords: isoform; tcf4; pdc; feedback regulation ... See more keywords
Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102544
Abstract: Summary Here we report a molecular docking-based approach to identify small molecules that can target the β-catenin (β-cat)-TCF4 protein-protein interaction (PPI), a key effector complex for nuclear Wnt signaling activity. Specifically, we developed and optimized… read more here.
Keywords: tcf4 interaction; tcf4; cat tcf4; interaction ... See more keywords
A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of NaV1.5 expression in HL-1 cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.08.007
Abstract: Increased nuclear β-catenin interacting with T-cell factor 4 (TCF4) affects the expression of target genes including SCN5A in ischemic heart disease, which is characterized by frequent ventricular tachycardia/fibrillation. A complex of β-catenin and TCF4 inhibits… read more here.
Keywords: catenin tcf4; activity; nav1 expression; tcf4 ... See more keywords
PROTAC moves in on lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00113-9
Abstract: For patients with diffuse large B cell lymphoma (DLBCL) that becomes refractory to standard therapy, outcomes are poor. Jain and colleagues analysed DNA copy number and gene expression, and found that transcription factor 4 (TCF4)… read more here.
Keywords: copy number; dlbcl; tcf4; brd4 ... See more keywords
The subcellular localization of bHLH transcription factor TCF4 is mediated by multiple nuclear localization and nuclear export signals
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52239-w
Abstract: Transcription factor 4 (TCF4) is a class I basic helix-loop-helix (bHLH) transcription factor which regulates the neurogenesis and specialization of cells. TCF4 also plays an important role in the development and functioning of the immune… read more here.
Keywords: transcription; tcf4; transcription factor; bhlh ... See more keywords
Building a schizophrenia genetic network: transcription factor 4 regulates genes involved in neuronal development and schizophrenia risk
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy222
Abstract: The transcription factor 4 (TCF4) locus is a robust association finding with schizophrenia (SCZ), but little is known about the genes regulated by the encoded transcription factor. Therefore, we conducted chromatin immunoprecipitation sequencing (ChIP-seq) of… read more here.
Keywords: schizophrenia; tcf4 binding; tcf4; transcription factor ... See more keywords
Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz381
Abstract: Abstract The psychiatric risk-associated transcription factor 4 (TCF4) is linked to schizophrenia. Rare TCF4 coding variants are found in individuals with Pitt-Hopkins syndrome—an intellectual disability and autism spectrum disorder. TCF4 contains a C-terminal basic-helix-loop-helix (bHLH)… read more here.
Keywords: structural basis; dna; tcf4; groove ... See more keywords
The recurrent TCF4 missense variant p.(Arg389Cys) causes a neurodevelopmental disorder overlapping with but not typical for Pitt‐Hopkins syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Genetics"
DOI: 10.1111/cge.14206
Abstract: TCF4 haploinsufficiency by deletions, truncating variants or loss‐of‐function missense variants within the DNA‐binding and protein interacting bHLH domain causes Pitt‐Hopkins syndrome (PTHS). This neurodevelopmental disorder (NDD) is characterized by severe intellectual disability (ID), epilepsy, hyperbreathing… read more here.
Keywords: bhlh domain; missense; missense variant; tcf4 ... See more keywords