TCF7l2, a nuclear marker that labels premyelinating oligodendrocytes and promotes oligodendroglial lineage progression
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24249
Abstract: Clinical and basic neuroscience research is greatly benefited from the identification and characterization of lineage specific and developmental stage‐specific markers. In the glial research community, histological markers that specifically label newly differentiated premyelinating oligodendrocytes are… read more here.
Keywords: premyelinating oligodendrocytes; oligodendroglial lineage; lineage; tcf7l2 ... See more keywords
A High-Throughput Genome-Integrated Assay Reveals Spatial Dependencies Governing Tcf7l2 Binding
Sign Up to like & getrecommendations! Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.08.004
Abstract: SUMMARY Predicting where transcription factors bind in the genome from their in vitro DNA-binding affinity is confounded by the large number of possible interactions with nearby transcription factors. To characterize the in vivo binding logic… read more here.
Keywords: tcf7l2; integrated assay; tcf7l2 binding; genome integrated ... See more keywords
The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/β-Catenin Signaling Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000475941
Abstract: Background/Aims: The long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) contributes to the proliferation and migration of tumors. However, its molecular mechanism underlying gastric cancer remains unknown. In the present study, we investigated whether CRNDE… read more here.
Keywords: tcf7l2; expression; crnde; wnt catenin ... See more keywords
TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.242297
Abstract: ABSTRACT Mesenchymal stromal cells (MSCs) are multipotent progenitors essential for organogenesis, tissue homeostasis, regeneration and scar formation. Tissue injury upregulates transforming growth factor β (TGF-β) signaling, which modulates myofibroblast fate, extracellular matrix remodeling and fibrosis.… read more here.
Keywords: expression; pdgfr fibroblasts; factor; tcf7l2 ... See more keywords
1898-P: The Role of the Diabetes Gene and Wnt Pathway Effector TCF7L2 in Hepatic Metabolic Zonation
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DOI: 10.2337/db19-1898-p
Abstract: The Transcription Factor 7-like 2 (TCF7L2) gene is associated with type 2 diabetes (T2D), but the function of the protein in metabolic tissues is controversial. The liver regulates whole body lipid and carbohydrate metabolism, and… read more here.
Keywords: metabolic zonation; hep e11; hepatic metabolic; tcf7l2 ... See more keywords
The Role of TCF7L2 in Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db20-0573
Abstract: TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that forms a basic part… read more here.
Keywords: type diabetes; tcf7l2; diabetes role; role tcf7l2 ... See more keywords