A Molecular Approach to Chronic T-cell Mediated Rejection
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DOI: 10.1097/01.tp.0000542962.00373.31
Abstract: Background Despite the advances in diagnosis of chronic antibody-mediated rejection (AMR), chronic T cell mediated rejection (TCMR) is solely defined by Banff classification as chronic allograft arteriopathy. We hypothesized that T cell-mediated immunity might play… read more here.
Keywords: tcmr; mediated rejection; cell mediated; expression ... See more keywords
Clinicopathological Analysis of Uterine Allografts Including Proposed Scoring of Ischemia Reperfusion Injury and T-cell–mediated Rejection—Dallas UtErus Transplant Study: A Pilot Study
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DOI: 10.1097/tp.0000000000003633
Abstract: Supplemental Digital Content is available in the text. Background. Uterus transplantation (UTx) enables pregnancy in infertile women. This study describes the histopathological changes of ischemia reperfusion injury and mostly acute T-cell–mediated rejection (TCMR) in UTx… read more here.
Keywords: reperfusion injury; ischemia reperfusion; cell mediated; reperfusion ... See more keywords
Relating Molecular T Cell–mediated Rejection Activity in Kidney Transplant Biopsies to Time and to Histologic Tubulitis and Atrophy-fibrosis
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DOI: 10.1097/tp.0000000000004396
Abstract: Background. We studied the variation in molecular T cell–mediated rejection (TCMR) activity in kidney transplant indication biopsies and its relationship with histologic lesions (particularly tubulitis and atrophy-fibrosis) and time posttransplant. Methods. We examined 175 kidney… read more here.
Keywords: time; atrophy fibrosis; tcmr activity; tcmr ... See more keywords
The Histological Spectrum and Clinical Significance of T Cell–mediated Rejection of Kidney Allografts
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DOI: 10.1097/tp.0000000000004438
Abstract: T cell–mediated rejection (TCMR) remains a significant cause of long-term kidney allograft loss, either indirectly through induction of donor-specific anti-HLA alloantibodies or directly through chronic active TCMR. Whether found by indication or protocol biopsy, Banff… read more here.
Keywords: tcmr; mediated rejection; cell mediated; acute tcmr ... See more keywords
Noninvasive Diagnosis of Acute Rejection in Renal Transplant Patients Using Mass Spectrometric Analysis of Urine Samples: A Multicenter Diagnostic Phase III Trial
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DOI: 10.1097/txd.0000000000001316
Abstract: Background. Timely recognition and treatment of acute kidney graft rejection is important to prevent premature graft failure. A predefined urinary marker set for acute T cell–mediated rejection (TCMR) containing 14 peptides was tested for this… read more here.
Keywords: diagnosis; marker set; rejection; urine samples ... See more keywords
Comprehensive Analysis of Transcript Changes Associated With Allograft Rejection: Combining Universal and Selective Features
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DOI: 10.1111/ajt.14200
Abstract: We annotated the top transcripts associated with kidney transplant rejection by p‐value, either universal for all rejection or selective for T cell–mediated rejection (TCMR) or antibody‐mediated rejection (ABMR; ClinicalTrials.gov NCT01299168). We used eight class‐comparison algorithms… read more here.
Keywords: tcmr; comprehensive analysis; analysis; rejection ... See more keywords
The negative impact of T cell–mediated rejection on renal allograft survival in the modern era
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DOI: 10.1111/ajt.16883
Abstract: The prevalence and long‐term impact of T cell–mediated rejection (TCMR) is poorly defined in the modern era of tacrolimus/mycophenolate‐based maintenance therapy. This observational study evaluated 775 kidney transplant recipients with serial histology and correlated TCMR… read more here.
Keywords: tcmr; modern era; cell mediated; mediated rejection ... See more keywords
Revisiting acute T cell–mediated rejection in kidney allografts
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DOI: 10.1111/ajt.16923
Abstract: In the early era of kidney transplantation, acute T cell– mediated rejection (TCMR) was the main clinical concern, significantly mitigated by potent immunosuppression since then. Today TCMR episodes are considered rare and clinically reversible but… read more here.
Keywords: treatment tcmr; tcmr; graft; treatment ... See more keywords
T cell–mediated rejection in kidney transplant recipients: The end(point) is also the beginning
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DOI: 10.1111/ajt.16964
Abstract: Advances in immunosuppression have reduced the rates and severity of clinically manifested acute T cell– mediated rejection (TCMR) in kidney transplant recipients to 5%– 15% in the first year. Lest we forget, acute TCMR remains… read more here.
Keywords: tcmr; graft; acute tcmr; treatment ... See more keywords
Preformed and de novo DSA are associated with T‐cell–mediated rejection in pediatric liver transplant recipients requiring clinically indicated liver biopsy
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DOI: 10.1111/petr.13611
Abstract: Despite growing interest about the impact of donor‐specific HLA antibodies (DSA) in LT limited data are available for pediatric recipients. Our aim was to perform a retrospective single‐center chart review of children (0‐16 years) having… read more here.
Keywords: tcmr; preformed novo; dsa; liver ... See more keywords
Hematological and biochemical characteristics and diagnostic imaging results in acute T cell-mediated rejection after pediatric liver transplantation.
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DOI: 10.1111/petr.14161
Abstract: BACKGROUND Liver biopsy is the gold standard for diagnosing TCMR after LT. However, complications caused by liver biopsy may occur especially during the immediate post-transplantation period and other effective methods for predicting TCMR have not… read more here.
Keywords: tcmr; acute tcmr; biochemical characteristics; hematological biochemical ... See more keywords