GluN2A‐Selective NMDA Receptor Antagonists: Mimicking the U‐Shaped Bioactive Conformation of TCN‐201 by a [2.2]Paracyclophane System
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200484
Abstract: Under physiological conditions, N‐Methyl‐D‐Aspartate (NMDA) receptors play a crucial role for synaptic plasticity, long‐term potentiation and long‐term depression. However, overactivation of NMDA receptors can result in excitotoxicity, which is associated with various neurological and neurodegenerative… read more here.
Keywords: nmda receptor; tcn 201; receptor antagonists; selective nmda ... See more keywords
Systematic variation of the benzoylhydrazine moiety of the GluN2A selective NMDA receptor antagonist TCN-201.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.09.006
Abstract: GluN2A containing N-methyl-D-aspartate receptors (NMDARs) are important ion channels in the central nervous system and highly involved in several different neurophysiological but also neuropathophysiological processes. However, current understanding of the contribution of GluN2A containing NMDARs… read more here.
Keywords: tcn 201; nmda receptor; negative allosteric; moiety ... See more keywords
Nucleus reuniens of the thalamus controls fear memory reconsolidation
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2020.107343
Abstract: The nucleus reuniens has been shown to support the acquisition, consolidation, maintenance, destabilization upon retrieval, and extinction of aversive memories. However, the direct participation of this thalamic subregion in memory reconsolidation is yet to be… read more here.
Keywords: memory reconsolidation; tcn 201; fear memory; nucleus reuniens ... See more keywords