Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21297-y
Abstract: Regulatory CD4+ T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers remain largely unclear. Here, we… read more here.
Keywords: conventional cells; clonal origin; breast cancer; cancer ... See more keywords
A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99134-x
Abstract: NF-kappaB (NF-κB) is a family of transcription factors with pleiotropic functions in immune responses. The alternative NF-κB pathway that leads to the activation of RelB and NF-κB2, was previously associated with the activation and function… read more here.
Keywords: relb; autoimmune encephalomyelitis; function; cell ... See more keywords
Distinguishing activated T regulatory cell and T conventional cells by single cell technologies.
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13460
Abstract: BACKGROUND Resting conventional T cells (Tconv) can be distinguished from T regulatory cells (Treg) by the canonical markers FOXP3, CD25 and CD127. However, the expression of these proteins alters after T cell activation leading to… read more here.
Keywords: treg; single cell; tconv; conventional cells ... See more keywords