A novel adoptive synthetic TCR and antigen receptor (STAR) T‐Cell therapy for B‐Cell acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26586
Abstract: We developed a T‐cell‐receptor (TCR) complex‐based chimeric antigen receptor (CAR) named Synthetic TCR and Antigen Receptor (STAR). Here, we report pre‐clinical and phase I clinical trial data (NCT03953599) of this T‐cell therapy for refractory and… read more here.
Keywords: cell; tcr; star; antigen receptor ... See more keywords
Intrahepatic T‐Cell Receptor β Immune Repertoire Is Essential for Liver Regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30067
Abstract: T lymphocytes synergize with the cellular immune system to promote hepatocyte regeneration. The T‐cell receptor (TCR) immune repertoire is closely associated with the host immune response and regenerative proliferation. High‐throughput sequencing of TCR provides deep… read more here.
Keywords: immune repertoire; liver regeneration; regeneration; cell receptor ... See more keywords
Neurometabolic profiles of the substantia nigra and striatum of MPTP‐intoxicated common marmosets: An in vivo proton MRS study at 9.4 T
Sign Up to like & getrecommendations! Published in 2017 at "NMR in Biomedicine"
DOI: 10.1002/nbm.3686
Abstract: Given the strong coupling between the substantia nigra (SN) and striatum (STR) in the early stage of Parkinson's disease (PD), yet only a few studies reported to date that have simultaneously investigated the neurochemistry of… read more here.
Keywords: mptp; group; mptp weeks; mrs ... See more keywords
T-cell receptor-silent peripheral T-cell lymphoma complicated with hemophagocytic lymphohystiocytosis
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-021-04628-3
Abstract: T-cell receptor (TCR) is associated with diverse antigen recognition in T-cells [1]. Peripheral T-cell lymphomas (PTCLs) are the neoplastic counterpart of postthymic T-cells [2] and usually express either αβ-TCR or γδ-TCR. However, rare cases of… read more here.
Keywords: cell receptor; cell; peripheral cell; tcr silent ... See more keywords
Towards a surrogate system to express human lipid binding TCRs
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Letters"
DOI: 10.1007/s10529-019-02713-2
Abstract: Previously we reported that natural nut lipids were necessary for sensitization and that natural killer T cells (NKTs) must play a critical role in the development of food allergic responses. A major bottleneck in further… read more here.
Keywords: system; human cell; surrogate system; cell ... See more keywords
NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular NMR"
DOI: 10.1007/s10858-019-00234-8
Abstract: Early studies of T cell structural biology using X-ray crystallography, surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) focused on a picture of the αβT cell receptor (αβTCR) component domains and their cognate ligands… read more here.
Keywords: studies cell; cell development; biology; ligand ... See more keywords
Modulation of room-temperature TCR and MR in La1−xSrxMnO3 polycrystalline ceramics via Sr doping
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Sol-Gel Science and Technology"
DOI: 10.1007/s10971-019-04955-y
Abstract: AbstractLa1−xSrxMnO3 (LSMO) polycrystalline samples with x content from 0.1 to 0.2 were synthesized via the optimized sol–gel method. The effect of Sr doping (x) on crystal structure, surface morphology, magnetic, and electrical transport properties of… read more here.
Keywords: xsrxmno3 polycrystalline; temperature; tcr; room temperature ... See more keywords
Reciprocal alterations in circulating and hepatic gamma–delta T cells in patients with primary biliary cholangitis
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology International"
DOI: 10.1007/s12072-021-10267-7
Abstract: Background and aims Gamma–delta (γδ) T cells are involved in the development of diverse liver and autoimmune diseases, whereas the role of γδ T cells in primary biliary cholangitis (PBC) remains unclear. Methods We analyzed… read more here.
Keywords: gamma delta; tcr low; tcr; primary biliary ... See more keywords
Atomic-resolution view of complete TCR-CD3 revealed
Sign Up to like & getrecommendations! Published in 2020 at "Protein & Cell"
DOI: 10.1007/s13238-019-00677-7
Abstract: Antigen-specific T-cell responses are triggered via interaction of T cell receptors (TCR) with pathogenor tumorderived peptides presented on major histocompatibility complexes (pMHC) by antigen-presenting cells (APCs). The mechanisms of TCR signaling are fundamentally important to… read more here.
Keywords: cd3 complex; tcr triggering; tcr cd3; structure ... See more keywords
In Vitro Formation of a Multi-Protein Complex Involved in TCR Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2878
Abstract: The T cell antigen receptor (TCR) binds a ligand consisting of antigenic peptide bound to a cell surface molecule encoded by the major histocompatibility complex (pMHC) to begin the process of T cell activation. TCR… read more here.
Keywords: protein; tcr; vitro formation; multi protein ... See more keywords
Height, but not binding epitope, affects the potency of synthetic TCR agonists.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.08.027
Abstract: Under physiological conditions, peptide-MHC (pMHC) molecules can trigger T-cell receptors (TCRs) as monovalent ligands that are sparsely distributed on the plasma membrane of an antigen-presenting cell. TCRs can also be triggered by artificial clustering, such… read more here.
Keywords: tcr agonists; synthetic tcr; binding epitope; fab dna ... See more keywords