A Costimulatory CAR Improves TCR-based Cancer Immunotherapy
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DOI: 10.1158/2326-6066.cir-21-0307
Abstract: This proof-of-concept study demonstrates that TCR-based therapies can be improved with engineered T cells expressing a costimulatory chimeric antigen receptor (CoCAR). CoCAR+ T cells are able to kill TCR targets, while sparing normal cells expressing… read more here.
Keywords: improves tcr; costimulatory car; car improves; costimulatory ... See more keywords
Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules
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DOI: 10.3390/antib11020034
Abstract: Bispecific T cell receptor (TCR)-based molecules capable of redirecting and activating T cells towards tumor cells represent a novel and promising class of biotherapeutics for the treatment of cancer. Usage of TCRs allows for targeting… read more here.
Keywords: maturation; tcr; display; bispecific ... See more keywords