827 Streamlining design of safe and effective TCR therapies with AI
Sign Up to like & getrecommendations! Published in 2021 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2021-sitc2021.827
Abstract: Adoptive cell therapies with T lymphocytes expressing engineered T cell receptors (TCRs) are one of the most promising approaches to cancer therapy.1 However, the experimentally driven development of novel TCR therapies is limited by the… read more here.
Keywords: phla tcr; tcr binding; cancer; prediction ... See more keywords
On TCR binding predictors failing to generalize to unseen peptides
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1014256
Abstract: Several recent studies investigate TCR-peptide/-pMHC binding prediction using machine learning or deep learning approaches. Many of these methods achieve impressive results on test sets, which include peptide sequences that are also included in the training… read more here.
Keywords: negative samples; unseen peptides; tcr binding; generalize unseen ... See more keywords