Use of TCR α+β+/CD19+–Depleted Haploidentical Hematopoietic Stem Cell Transplant Is a Viable Option in Patients With Primary Immune Deficiency Without Matched Sibling Donor
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-019-00648-x
Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is curative for many patients with primary immune deficiency (PID). Haploidentical donors have historically been associated with higher rates of graft-versus-host disease (GvHD) and graft failure. Use of T… read more here.
Keywords: use; tcr cd19; cd19 depleted; hematopoietic stem ... See more keywords
Successful TCRαβ/CD19-Depleted Hematopoietic Cell Transplantation for a Patient With Artemis Deficiency.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of pediatric hematology/oncology"
DOI: 10.1097/mph.0000000000002522
Abstract: Artemis deficiency is characterized by DNA double-strand breaks repairing dysfunction and increased sensitivity to ionizing radiation and alkylating reagents. We describe the first successful case of T-cell receptor [TCR]αβ/CD19-depleted hematopoietic cell transplantation [HCT] for Artemis… read more here.
Keywords: artemis deficiency; cell; tcr cd19; cd19 depleted ... See more keywords
KIR-Favorable TCR-αβ/CD19-Depleted Haploidentical HCT in Children with ALL/AML/MDS: Primary Analysis of PTCTC ONC1401.
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DOI: 10.1182/blood.2022015959
Abstract: The Pediatric Transplantation and Cellular Therapy Consortium (PTCTC) performed a prospective multicenter study of TCR-αβ/CD19-depleted haploidentical HCT in children with acute leukemia and myelodysplastic syndrome (MDS) to determine 1-year disease free survival (DFS) and compare… read more here.
Keywords: tcr cd19; cd19 depleted; analysis; depleted haploidentical ... See more keywords