Lactoferrin‐derived chimeric peptide (LFch) strongly boosts TGFβ1‐mediated inducible Treg differentiation possibly through downregulating TCR/CD28 signalling
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13566
Abstract: We recently reported that lactoferrin (LF) induces Foxp3+ Treg differentiation through binding to TGFβ receptor III (TβRIII), and this activity was further enhanced by TGFβ1. Generally, a low T‐cell receptor (TCR) signal strength is favourable… read more here.
Keywords: lfch; treg differentiation; foxp3 treg; tgf ... See more keywords
Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1170821
Abstract: Staphylococcus aureus superantigens (SAgs) such as staphylococcal enterotoxin A (SEA) and B (SEB) are potent toxins stimulating T cells to produce high levels of inflammatory cytokines, thus causing toxic shock and sepsis. Here we used… read more here.
Keywords: antigen presenting; signals independently; presenting cells; staphylococcal sags ... See more keywords