Atomic-resolution view of complete TCR-CD3 revealed
Sign Up to like & getrecommendations! Published in 2020 at "Protein & Cell"
DOI: 10.1007/s13238-019-00677-7
Abstract: Antigen-specific T-cell responses are triggered via interaction of T cell receptors (TCR) with pathogenor tumorderived peptides presented on major histocompatibility complexes (pMHC) by antigen-presenting cells (APCs). The mechanisms of TCR signaling are fundamentally important to… read more here.
Keywords: cd3 complex; tcr triggering; tcr cd3; structure ... See more keywords
T Cell Receptor Clustering - A Mechanism of Signal Transduction
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.235
Abstract: Antigen recognition by the T cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major histocompatibility complex molecule (pMHC), it transmits a signal… read more here.
Keywords: tcr cd3; cd3; cell receptor;
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109375
Abstract: Summary The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide T cell antigen receptor (pMHC)-induced signaling not explicable… read more here.
Keywords: tcr cd3; cd3; antigen receptor; cell antigen ... See more keywords
Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.11.008
Abstract: How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active… read more here.
Keywords: cd3; model tcr; tcr cd3; dissociative model ... See more keywords
Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes
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DOI: 10.1038/s41598-019-45260-6
Abstract: Toll-like receptor 4 (TLR4) is involved in CD4+ T lymphocyte-mediated pathologies. Here, we demonstrate that CD4+ T lymphocytes express functional TLR4 that contributes to their activation, proliferation and cytokine secretion. In addition, we demonstrate that… read more here.
Keywords: cd4 lymphocytes; tcr cd3; mediated activation; cd3 mediated ... See more keywords
The T cell receptor displays lateral signal propagation involving non-engaged receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr05855j
Abstract: T cells are highly sensitive to low levels of antigen, but how this sensitivity is achieved is currently unknown. Here, we imaged proximal TCR-CD3 signal propagation with single molecule localization microscopy (SMLM) in T cells… read more here.
Keywords: tcr cd3; signal propagation; lateral signal; non engaged ... See more keywords
FRI0010 TCR-CD3Z GENE EXPRESSION PROFILE IN A COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.379
Abstract: Background Advances in understanding the pathogenesis of RA support the contribution of T cells in the disease process through the recognition of the arthritogenic antigen (Ag) and maintenance of chronic inflammatory response [1]. Previous gene… read more here.
Keywords: expression; tcr; gene; rheumatoid arthritis ... See more keywords