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   Articles with "tcr cell" as a keyword



Sequential Dosing of Next-Generation IMA203CD8 TCR-T-Cell Therapy Targeting PRAME in Combination with BRAF-/MEK-Inhibition in a Melanoma Patient with Progressive Disease - a Case Report

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-194461

Abstract: Background: T-cell-receptor (TCR)- T-cell therapies have shown promising results in cancer patients, most notably to date in patients with advanced melanoma. However, there is little data on delayed sequential dosing of TCR-T-cell therapies in patients… read more here.

Keywords: tcr cell; infusion; cell; tcr ... See more keywords

Single center evaluation of TCRαβ+ T cell depletion using CliniMACS® plus platform: Optimizing cell selection for hematopoietic stem cell transplantation

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-4215

Abstract: Introduction TCRαβ+ T cell-depletion is a promising ex vivo graft engineering technique that effectively reduces the risk of graft-versus-host disease (GVHD) in haplo-hematopoietic stem cell transplantation. However, the magnetic sorting process typically results in a… read more here.

Keywords: cell depletion; tcr cell; stem cell; cell ... See more keywords

Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.896242

Abstract: Cellular immunotherapies based on T cell receptor (TCR) transfer are promising approaches for the treatment of cancer and chronic viral infections. The discovery of novel receptors is expanding considerably; however, the clinical development of TCR-T… read more here.

Keywords: tcr cell; scale manufacturing; cell; tcr ... See more keywords

TCR-T cell therapy for solid tumors: challenges and emerging solutions

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recommendations! Published in 2025 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2025.1493346

Abstract: With the use of T cell receptor T cells (TCR-T cells) and chimeric antigen receptor T cells (CAR-T cells), T-cell immunotherapy for cancer has advanced significantly in recent years. CAR-T cell therapy has demonstrated extraordinary… read more here.

Keywords: cell therapy; therapy; tcr cell; solid tumors ... See more keywords