614 Co-stimulation via PD1–41BB chimeric switch receptor enhances function of TCR-T cells in an immune-suppressive milieu and under chronic antigen stimulation
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0614
Abstract: Background The immunosuppressive tumor microenvironment (TME) of solid tumors negatively influences the efficacy and fitness of tumor-specific T cells and can render them non-functional. In this repressive tumor milieu, expression of inhibitory immune checkpoint molecules… read more here.
Keywords: pd1 41bb; switch receptor; tcr cells;
NY-ESO-1-specific redirected T cells with endogenous TCR knockdown mediate tumor response and cytokine release syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003811
Abstract: Background Because of the shortage of ideal cell surface antigens, the development of T-cell receptor (TCR)-engineered T cells (TCR-T) that target intracellular antigens such as NY-ESO-1 is a promising approach for treating patients with solid… read more here.
Keywords: tumor response; cell; tcr; tcr cells ... See more keywords
Engineering second-generation TCR-T cells by site-specific integration of TRAF-binding motifs into the CD247 locus
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005519
Abstract: Background The incorporation of co-stimulatory signaling domains into second-generation chimeric antigen receptors (CARs) significantly enhances the proliferation and persistence of CAR-T cells in vivo, leading to successful clinical outcomes. Methods To achieve such functional enhancement… read more here.
Keywords: second generation; tcr; tcr cells; cd247 locus ... See more keywords
Dual receptor T cells mediate effective antitumor immune responses via increased recognition of tumor antigens
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DOI: 10.1136/jitc-2022-006472
Abstract: Background Discovery that ~16% of T cells naturally co-express two T-cell receptor (TCR) clonotypes prompts examining the role of dual TCR cells in immune functions. Methods Using TCRα-reporter transgenic mice, enabling unambiguous identification of single-TCR and… read more here.
Keywords: tcr; dual tcr; tcr cells; antitumor immune ... See more keywords
ScRNA-seq reveals novel immune-suppressive T cells and investigates CMV-TCR-T cells cytotoxicity against GBM
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DOI: 10.1136/jitc-2024-008967
Abstract: Background Glioblastoma (GBM) is a fatal primary brain malignancy in adults. Previous studies have shown that cytomegalovirus (CMV) is a risk factor for tumorigenesis and aggressiveness for glioblastoma. However, little is known about how CMV… read more here.
Keywords: cmv tcr; gbm; tcr cells; tcr ... See more keywords
HBV-Specific TCR–T Cell Therapy Combining mRNA Electroporation and Lentiviral Transduction: Treatment Regimen for Recurrent HBV-Related HCC after Liver Transplantation
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DOI: 10.1158/1078-0432.ccr-25-1245
Abstract: Abstract Purpose: This study aimed to preliminarily evaluate the safety, tolerability, and antitumor efficacy of hepatitis B virus (HBV)-specific T-cell receptor (TCR)–T cell therapy combining mRNA electroporation and lentiviral transduction in patients with recurrent HBV–hepatocellular… read more here.
Keywords: treatment; tcr; hbv specific; tcr cells ... See more keywords
Abstract 2204: Enhancing anti-tumor efficacy of MART-1-specific TCR-T cells by CRISPR-Cas9-based PD-1 disruption
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-2204
Abstract: T cell function can be compromised when continuously exposed to tumor antigens by immune checkpoint signaling. Immunotherapies with T cells and inhibitors of repressive checkpoint molecules such as PD-1, CTLA-4, etc. have been shown promising… read more here.
Keywords: disruption; tcr cells; tcr; anti tumor ... See more keywords
Abstract 4057: T cells co-expressing a highly potent NY-ESO-1-specific TCR and a chimeric PD1-41BB co-stimulatory switch receptor show a favorable polyfunctional profile for the treatment of solid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4057
Abstract: T cell receptor (TCR)-based immunotherapies have shown great potential for the safe and efficacious treatment of patients suffering from various solid malignancies. However, novel strategies are needed to overcome the immunosuppressive tumor microenvironment (TME) and… read more here.
Keywords: eso; cell; tcr; pd1 41bb ... See more keywords
Abstract 914: Preinfusion polyfunctional profiles and cytokine secretion activity of transgenic TCR-T cells, and serum cytokine profiles, are associated with clinical outcomes in sarcoma and melanoma
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DOI: 10.1158/1538-7445.am2023-914
Abstract: Background: Transgenic TCR-T cells targeting MART-1 and NY-ESO-1 for the treatment of melanoma and sarcoma, respectively, are associated with robust initial clinical responses. However, these responses are often not durable, and a significant proportion of… read more here.
Keywords: cell; serum cytokine; tcr; preinfusion ... See more keywords
Abstract 4868: Optimal activation of TCR T cells in solid tumors through addition of best-in-class single chain CD8 coreceptors results in CD4 engagement and improved T cell fitness and persistence
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4868
Abstract: Clinical response rates in solid tumors have been improved and/or broadened by including either CD8α or wild type CD8αβ co-receptors (CoR) in T cell receptor (TCR) T cell therapy constructs, enabling engagement of CD4 T… read more here.
Keywords: cd8; cell; cor; tcr cells ... See more keywords
Myocardial Milieu Favors Local Differentiation of Regulatory T Cells
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DOI: 10.1161/circresaha.122.322183
Abstract: Background: In the past years, several studies investigated how distinct immune cell subsets affects post–myocardial infarction repair. However, whether and how the tissue environment controls these local immune responses has remained poorly understood. We sought… read more here.
Keywords: myocardial milieu; tcr cells; cell; regulatory phenotype ... See more keywords