Enhancing Efficacy of TCR-engineered CD4+ T Cells Via Coexpression of CD8α
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunotherapy (Hagerstown, Md. : 1997)"
DOI: 10.1097/cji.0000000000000456
Abstract: Adoptive cell therapy with T cells expressing affinity-enhanced T-cell receptors (TCRs) is a promising treatment for solid tumors. Efforts are ongoing to further engineer these T cells to increase the depth and durability of clinical… read more here.
Keywords: cell; cd4 cells; efficacy; tcr engineered ... See more keywords
TCR-engineered T cell therapy in solid tumors: State of the art and perspectives
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf3700
Abstract: T cell engineering has changed the landscape of cancer immunotherapy. Chimeric antigen receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell malignancies in hematology. However, their clinical impact on solid… read more here.
Keywords: engineered cell; cell; cell therapy; therapy solid ... See more keywords
Abstract A009: AFNT-111: A novel TCR-engineered T cell therapy targeting the oncogenic driver KRAS G12V
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-a009
Abstract: Mutations in the RAS family are highly prevalent in human cancers, including up to 35% of non-small cell lung, 45% of colorectal, and 95% of pancreatic cancers. Kirsten rat sarcoma viral oncogene homologue (KRAS) is… read more here.
Keywords: cell; afnt 111; tumor; tcr engineered ... See more keywords
Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.835762
Abstract: To redirect T cells against tumor cells, T cells can be engineered ex vivo to express cancer-antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T cells (TCR T). Unlike chimeric antigen receptors… read more here.
Keywords: cancer; engineered cells; tcr; cancer therapy ... See more keywords
Emerging Strategies in TCR-Engineered T Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.850358
Abstract: Immunotherapy of cancer has made tremendous progress in recent years, as demonstrated by the remarkable clinical responses obtained from adoptive cell transfer (ACT) of patient-derived tumor infiltrating lymphocytes, chimeric antigen receptor (CAR)-modified T cells (CAR-T)… read more here.
Keywords: tumor specific; engineered cells; emerging strategies; strategies tcr ... See more keywords
Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15041031
Abstract: Simple Summary Neoantigens are considered good targets for immunotherapy due to their tumor specificity. However, because neoantigens are unique in individual cancers, it is challenging to select personalized target neoantigens. In this study, we focused… read more here.
Keywords: fgfr3y373c; cell; cancer; shared neoantigens ... See more keywords