Engineering antigen‐specific NK cell lines against the melanoma‐associated antigen tyrosinase via TCR gene transfer
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948140
Abstract: Introduction of Chimeric Antigen Receptors to NK cells has so far been the main practical method for targeting NK cells to specific surface antigens. In contrast, T cell receptor (TCR) gene delivery can supply large… read more here.
Keywords: cell; antigen; antigen specific; tcr gene ... See more keywords
TCR gene segment usage and HLA alleles that are associated with cancer survival rates also represent racial disparities
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12610
Abstract: Understanding racial disparities in cancer outcomes continues to be a challenge, with likely many factors at play, including socioeconomic factors and genetic polymorphisms impacting basic cellular and molecular functions. Additionally, it is possible that specific… read more here.
Keywords: cancer; racial disparities; tcr gene; gene segment ... See more keywords
Abstract A21: Engineering antigen-specific natural killer cells against the melanoma-associated antigen tyrosinase via TCR gene transfer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-a21
Abstract: Introduction of chimeric antigen receptors (CARs) to natural killer (NK) cells has so far been the only practical method for specific targeting of NK cells against surface antigens. In contrast, T-cell receptor (TCR) gene therapy… read more here.
Keywords: antigen specific; immunology; antigen; tcr gene ... See more keywords
Capture Sequencing Is a Useful Method for Comprehensive Clonality Analysis Based on Ig/TCR Gene Rearrangements in Acute Lymphoblastic Leukemia
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DOI: 10.1182/blood-2018-99-115624
Abstract: Introduction Immunoglobulin (Ig)/ T-cell receptor (TCR) gene rearrangements are the most widely used clonal marker to detect residual leukemic cells in patients with Acute Lymphoblastic Leukemia (ALL). Ig/TCR gene rearrangements based molecular minimum residual disease… read more here.
Keywords: capture sequencing; mrd; gene rearrangements; tcr gene ... See more keywords
A Phase I Study Evaluating the Safety and Persistence of Allorestricted WT1-TCR Gene Modified Autologous T Cells in Patients with High-Risk Myeloid Malignancies Unsuitable for Allogeneic Stem Cell Transplantation
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DOI: 10.1182/blood-2019-128044
Abstract: Background:Patients with acute myeloid leukemia (AML), myelodysplasia (MDS) or tyrosine kinase inhibitor resistant chronic myeloid leukemia (CML) who are unsuitable for consolidative allogeneic stem cell transplantation (alloSCT) have high relapse rates following chemotherapy. Wilms' tumor… read more here.
Keywords: tcr gene; cell; gene modified; wt1 tcr ... See more keywords
Autoreactive CD8 T cells in NOD mice exhibit phenotypic heterogeneity but restricted TCR gene usage
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DOI: 10.26508/lsa.202201503
Abstract: Paired scRNA-seq and scTCR-seq reveals that diabetogenic CD8 T cells in the islets and spleens of NOD mice exhibit phenotypic and clonal heterogeneity despite restricted TCR gene usage. Expression of certain TCR genes correlates with… read more here.
Keywords: seq; tcr gene; restricted tcr; cells islets ... See more keywords