TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.08.050
Abstract: Summary MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8+ MAIT… read more here.
Keywords: mait cells; mait; tissue; tcr independent ... See more keywords
γδTCR-independent origin of neonatal γδ T cells prewired for IL-17 production.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2019.04.011
Abstract: A classical view of T cell lineages consists of two major clades of T cells expressing either the αβ or γδ T cell receptor (TCR). However, genome-wide assessments indicate molecular clusters segregating T cell subsets… read more here.
Keywords: independent origin; origin neonatal; neonatal cells; cells prewired ... See more keywords
TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-21-0813
Abstract: Myc-driven B-cell lymphoma is demonstrated to induce selective and early TCR-independent metabolic suppression of CD4+ T cells. This process precedes changes to T-cell fate and function and occurs before significant changes in tumor burden. read more here.
Keywords: independent metabolic; cell fate; changes cell; metabolic reprogramming ... See more keywords