TCR‐induced alteration of primary MHC peptide anchor residue
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DOI: 10.1002/eji.201948085
Abstract: The HLA‐A*02:01‐restricted decapeptide EAAGIGILTV, derived from melanoma antigen recognized by T‐cells‐1 (MART‐1) protein, represents one of the best‐studied tumor associated T‐cell epitopes, but clinical results targeting this peptide have been disappointing. This limitation may reflect… read more here.
Keywords: peptide; tcr induced; antigen; induced alteration ... See more keywords
TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity
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DOI: 10.3389/fcell.2021.789348
Abstract: Small ubiquitin-like modifier (SUMO) modification plays an important regulatory role in T cell receptor (TCR) signaling transduction. SUMO-specific proteases (SENPs) have dual-enzyme activities; they can both process SUMO precursors as endopeptidases and participate in SUMO… read more here.
Keywords: senp1; tcr induced; activity; phosphorylation ... See more keywords
Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells
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DOI: 10.3389/fimmu.2019.00162
Abstract: Notch receptors signaling is required for optimal T-cell activation and function. T-cell receptor (TCR) engagement can activate Notch receptors in T-cells in a ligand-independent fashion. In this study, we examined the role of adenosine A2A… read more here.
Keywords: cd8 cells; tcr induced; induced notch1; activation ... See more keywords
TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells
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DOI: 10.3389/fimmu.2022.913184
Abstract: T cell activation is dependent upon the integration of antigenic, costimulatory and cytokine-derived signals and the availability and acquisition of nutrients from the environment. Furthermore, T cell activation is accompanied by reprogramming of cellular metabolism… read more here.
Keywords: tcr; myc dependent; cell activation; tcr induced ... See more keywords
Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity
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DOI: 10.7554/elife.23190
Abstract: T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young’s modulus range… read more here.
Keywords: different tcr; stiffness; tcr induced; induced lymphocyte ... See more keywords