A TCR-like antibody against a proinsulin-containing fusion peptide ameliorates type 1 diabetes in NOD mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.019
Abstract: Type 1 diabetes (T1D) is an autoimmune disease caused by destruction of insulin-producing β cells. The response of autoreactive T cells to β cell antigens plays a central role in the development of T1D. Recently,… read more here.
Keywords: tcr like; fusion peptide; type diabetes; fusion ... See more keywords
TCR-like antibody drug conjugates mediate killing of tumor cells with low peptide/HLA targets
Sign Up to like & getrecommendations! Published in 2017 at "mAbs"
DOI: 10.1080/19420862.2017.1302630
Abstract: ABSTRACT The currently marketed antibody-drug conjugates (ADC) destabilize microtubule assembly in cancer cells and initiate apoptosis in patients. However, few tumor antigens (TA) are expressed at high densities on cancer lesions, potentially minimizing the therapeutic… read more here.
Keywords: drug conjugates; tcr like; like antibody; antibody drug ... See more keywords
Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004035
Abstract: Background The current therapeutic antibodies and chimeric antigen receptor (CAR) T cells are capable of recognizing surface antigens, but not of intracellular proteins, thus limiting the target coverage for drug development. To mimic the feature… read more here.
Keywords: antigen; tcr like; car cells; cancer ... See more keywords
Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Immunology Research"
DOI: 10.1155/2020/2454907
Abstract: Retargeting the antigen-binding specificity of T cells to intracellular antigens that are degraded and presented on the tumor surface by engineering chimeric antigen receptor (CAR), also named TCR-like antibody CAR-T, remains limited. With the exception… read more here.
Keywords: like car; tcr like; antibody; single domain ... See more keywords