TCR–pMHC bond conformation controls TCR ligand discrimination
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-019-0273-6
Abstract: A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC… read more here.
Keywords: bond; bond conformation; tcr pmhc; tcr ... See more keywords
Fluctuations in T cell receptor and pMHC interactions regulate T cell activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2021.0589
Abstract: Adaptive immune responses depend on interactions between T cell receptors (TCRs) and peptide major histocompatibility complex (pMHC) ligands located on the surface of T cells and antigen presenting cells (APCs), respectively. As TCRs and pMHCs… read more here.
Keywords: cell; pmhc; cell activation; tcr pmhc ... See more keywords